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Summary The amino acid sequence used is 92% homologous in DcTrailR2.

Summary The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

Summary This antibody is expected to recognise variant 1 (NP_115584) only.

Summary This antibody reacts with 70 and 200 kDa component of the neurofilament polypeptide subunit. It stains neurons, neuronal processes and peripheral nerves. This antibody reacts with some neuroblastomas and gangliomas but not with other non-neuronal tumors.