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Summary This antibody recognizes two variants of prekallikrein in human plasma, 88kDa and 85kDa, and its activation products kallikrein, the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45kDa prekallikrein/kallikrein fragments.The epitope for this antibody is located on the prekallikrein/kallikrein heavy chain and is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by ~60- 80% and 55%, respectively. This antibody does not cross-react with tissue kallikrein.

Summary Its epitope is resistant to digestion by trypsin and chymotrypsin. This antibody selectively interferes with lymphocyte binding to lymph node, mucosal and synovial endothelium.

Summary This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family.