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Summary This antibody recognizes heavy chain of conventional kinesin associated with vesicles and with lower affinity with denaturated molecule. Epitope is located in coiled-coil stalk domain. It stains Western blots of kinesin-enriched preparations. Epitope mapping (by limited proteolysis of partially purified porcine kinesin) followed by immunoblotting has revealed that antibodies KN-01, KN-02 and KN-03 react with different sets of fragments. The antibody KN-02 does not react with kinesin bound to taxol-stabilized microtubules.

Summary ACACA

Summary This antibody recognizes an epitope in the alpha subunits of IGF1R.Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to IGF1 Receptor (Li et al.1993).

Summary The mAB35 antibody binds to the major immunogenic region of the α subunits. It has been shown to passively transfer experimental autoimmune myasthenia gravis.

Summary This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity of this antibody for IR by approximately 100 fold. This antibody reacts with autophosphorylated IR, unoccupied IR, and the insulin IR complex. It has no effect on insulin-stimulated autophosphorylation.

Summary Clone 7F8, D4B8, 3A6 and 8E2 react with different antigenic determinants. These antibodies react with insulin/proinsulin but not react with free C-peptide.

Summary Recognises the 85kDa cleaved fragment of Low Density LRP (extracellular domain).

Summary Recognises the 85kDa cleaved fragment of Low Density LRP (extracellular domain).