PRODUCT
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Positive Control
Kidney: An at least weak to moderate nuclear AR immunostaining should be seen in a subset of kidney tubuli and of glomerular cells.
Negative Control
Colon: AR immunostaining should be absent in colonic mucosa.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.05% BSA (Please contact us for PBS only format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide corresponding to residues (within aa1-100) of Androgen Receptor.
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
androgen receptor , AIS , AR8 , DHTR , HUMARA , HYSP1 , KD , NR3C4 , SBMA , SMAX1 , TFM
Cellular Localization
Nucleus , Cytoplasm
Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Database
Research Area
DATA IMAGES
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/templates/default/js/lightbox/images/loading.gif "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
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GTX04368 IHC-P Image
IHC-P analysis of human colonic mucosa tissue using GTX04368 Androgen Receptor antibody [MSVA-367R] HistoMAX™.
Complete absence of androgen receptor staining in normal colon mucosa.
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GTX04368 IHC-P Image
IHC-P analysis of human prostatic adenocarcinoma (PAC) tissue with (Gleason 4+4=8) tissue using GTX04368 Androgen Receptor antibody [MSVA-367R] HistoMAX™.
A strong nuclear AR immunostaining is seen in all cells of a prostatic adenocarcinoma (Gleason 4+4=8).
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GTX04368 IHC-P Image
IHC-P analysis of human prostate tissue using GTX04368 Androgen Receptor antibody [MSVA-367R] HistoMAX™.
A strong nuclear androgen receptor immunostaining is seen in stromal and epithelial cells of the prostate.
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REFERENCE
There are currently no references for Androgen Receptor antibody [MSVA-367R] HistoMAX™ (GTX04368). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Androgen Receptor antibody [MSVA-367R] HistoMAX™ (GTX04368). Be the first to share your experience with this product.
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/small/GTX04368/GTX04368_20230728_IHC-P_133_23072722_267.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/small/GTX04368/GTX04368_20230728_IHC-P_263_23072722_965.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/small/GTX04368/GTX04368_20230728_IHC-P_3_23072722_392.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/normal/GTX04368/GTX04368_20230728_IHC-P_133_23072722_267.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/normal/GTX04368/GTX04368_20230728_IHC-P_263_23072722_965.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")
![Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368](/upload/website/prouct_img/normal/GTX04368/GTX04368_20230728_IHC-P_3_23072722_392.webp "Anti-Androgen Receptor antibody [MSVA-367R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04368")