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CTLA4 antibody [MSVA-152R] HistoMAX

Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439
Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439
Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439

Cat. No. GTX04439

Host

Rabbit

Clonality

Monoclonal

Clone Name

MSVA-152R

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
500 μl ($1859),
100 μl ($459)
PRODUCT

Summary

This antibody was validated on 76 different Normal and cancerTissues by IHC-P.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50-1:100

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.

This antibody has been validated by Autostainer including Agilent/Dako - Autostainer Link 48, Bond RX-Lecia, and Roche-Ventana Discovery ULTRA. The detailed steps by Autostainer please refer to the protocol.

Not tested in other applications.

Calculated MW

25 kDa. ( Note )

Positive Control

Tonsil: A moderate strong membranous and cytoplasmic CTLA4 immunostaining should be seen in a subset of T-lymphocytes with strongest staining in follicular T-helper cells of germinal centres.

Negative Control

Tonsil: The majority of lymphocytes in germinal centres and all epithelial cells should stain negative.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human CTLA4 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cytotoxic T-lymphocyte associated protein 4 , ALPS5 , CD , CD152 , CELIAC3 , CTLA-4 , GRD4 , GSE , IDDM12

Cellular Localization

Cell membrane

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439

GTX04439 IHC-P Image

IHC-P analysis of human Hodgkin's lymphoma tissue section using GTX04439 CTLA4 antibody [MSVA-152R] HistoMAX.
Hodgkins lymphoma containing numerous reactive CTLA4 positive lymphocytes.

Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439

GTX04439 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX04439 CTLA4 antibody [MSVA-152R] HistoMAX.
Normal tonsil with CTLA4 staining of a subset of lymphocytes.

Anti-CTLA4 antibody [MSVA-152R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04439

GTX04439 IHC-P Image

IHC-P analysis of human diffuse large B-cell lymphoma tissue section using GTX04439 CTLA4 antibody [MSVA-152R] HistoMAX.
Diffuse large B cell lymphoma containing a large number of CTLA4 positive lymphocytes.

REFERENCE

There are currently no references for CTLA4 antibody [MSVA-152R] HistoMAX (GTX04439). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CTLA4 antibody [MSVA-152R] HistoMAX (GTX04439). Be the first to share your experience with this product.
Package List Price ($)
$ 1859
$ 459