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Chromogranin A antibody [MSVA-380R] HistoMAX™

HistoMAX
Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370
Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370
Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370

Cat. No. GTX04370

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 MSVA-380R

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($679),
100 μl ($299)
See all Chromogranin A products
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 9.0 Tris-EDTA-based Target Retrieval Solution buffer. Based on the testing result, the pH 9.0 is optimal but pH 7.8 results in only slightly weaker stainings. At pH 6.0, the immunostaining is markedly reduced.
Not tested in other applications.

Calculated MW

51 kDa. ( Note )

Positive Control

Appendix: An at least weak to moderate staining must be seen in the axons and ganglion cells of the peripheral nerves while mucosal neuroendocrine cells exhibit a strong staining (neuroendocrine cells are not sufficient as positive controls because they express CGA so strongly, that even inefficient staining will detect its expression)

Negative Control

Appendix: Epithelial and smooth muscle cells should be negative.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full-length human chromogranin A protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chromogranin A , CGA

Cellular Localization

Secreted

Background

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Database

Research Area

DATA IMAGES

Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370

GTX04370 IHC-P Image

IHC-P analysis of human appendix tissue section using GTX04370 Chromogranin A antibody [MSVA-380R] HistoMAX™.
Neuroendocrine tumor of the appendix showing strong chromogranin A immunostaining.

Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370

GTX04370 IHC-P Image

IHC-P analysis of human pancreas tissue section using GTX04370 Chromogranin A antibody [MSVA-380R] HistoMAX™.
Islet cells of the pancreas show intense chromogranin A staining.

Anti-Chromogranin A antibody [MSVA-380R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04370

GTX04370 IHC-P Image

IHC-P analysis of human stomach antrum glands tissue section using GTX04370 Chromogranin A antibody [MSVA-380R] HistoMAX™.
Strong chromogranin A expression in scattered neuroendocrine cells of stomach antrum glands.

REFERENCE

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REVIEW

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Package List Price ($)
$ 679
$ 299