APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
Not tested in other applications.
Predict Reactivity
Mouse, Rat, Rabbit, Bovine, Dog, Pig, Chimpanzee, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 2% BSA
Preservative
0.025% ProClin 300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent
Antigen Species
Human
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GPX2. The exact sequence is proprietary.
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
glutathione peroxidase 2 ,GI-GPx ,GPRP ,GPRP-2 ,GPx-2 ,GPx-GI ,GSHPX-GI ,GSHPx-2
Cellular Localization
Cytoplasm
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Database
Research Area
DATA IMAGES
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/templates/default/js/lightbox/images/loading.gif "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
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GTX639924 IHC-P Image
IHC-P analysis of human colon descendens mucosa tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
Strong predominantly cytoplasmic GPX2 staining of epithelial cells - predominantly in the crypts. A luminal membrane staining can also be seen.
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GTX639924 IHC-P Image
IHC-P analysis of human bronchus glands tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
In some cases, all cells of the respiratory epithelium show intense nuclear and cytoplasmic GPX2 staining.
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GTX639924 IHC-P Image
IHC-P analysis of human stomach antrum tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
Strong GPX2 staining of the surface epithelium with strongest staining in the most superficial cells. Parietal cells do also show significant staining.
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REFERENCE
There are currently no references for GPX2 antibody [HMV301] HistoMAX™ (GTX639924). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for GPX2 antibody [HMV301] HistoMAX™ (GTX639924). Be the first to share your experience with this product.
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_2_24040301_403.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_1_24040301_822.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_24040301_103.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_2_24040301_403.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_1_24040301_822.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_24040301_103.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")