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MUC1 antibody [MSVA-672R] HistoMAX™

Recombinant antibody HistoMAX
Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397
Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397
Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397

Cat. No. GTX04397

Host

Rabbit

Clonality

Monoclonal

Clone Name

MSVA-672R

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
500 μl ($519),
100 μl ($299)
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:75-1:150

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 9.0 Tris-EDTA-based Target Retrieval Solution buffer. Based on the testing result, the pH 9.0 showed a strongest staining pattern. The pH 7.8 and pH 6.0 is acceptable without resulting in a significant reduction of sensitivity.

Not tested in other applications.

Calculated MW

122 kDa. ( Note )

Positive Control

Kidney: Distal tubuli and collecting ducts must show a strong cytoplasmic MUC1 staining while the staining should be at least moderate in the parietal and visceral sheets of the Bowman’s capsule and largely absent in proximal tubuli.

Negative Control

Colon: MUC1 staining should be very weak or absent in colonic epithelium.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA (Please contact us for PBS only format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human MUC1 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mucin 1, cell surface associated , ADMCKD , ADMCKD1 , CA 15-3 , CD227 , EMA , H23AG , KL-6 , MAM6 , MCD , MCKD , MCKD1 , MUC-1 , MUC-1/SEC , MUC-1/X , MUC1/ZD , PEM , PEMT , PUM

Cellular Localization

Apical cell membrane , Secreted , Cytoplasm , Nucleus

Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397

GTX04397 IHC-P Image

IHC-P analysis of human kidney cortex tissue section using GTX04397 MUC1 antibody [MSVA-672R] HistoMAX™.

Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397

GTX04397 IHC-P Image

IHC-P analysis of human malignant mesothelioma epitheloid tissue section using GTX04397 MUC1 antibody [MSVA-672R] HistoMAX™.
Malignant mesothelioma epitheloid variant with strong predominantly membranous MUC1 immunostaining of tumor cells.

Anti-MUC1 antibody [MSVA-672R] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04397

GTX04397 IHC-P Image

IHC-P analysis of human pancreas tissue section using GTX04397 MUC1 antibody [MSVA-672R] HistoMAX™.
Pancreatic acinar cells show a strong MUC1 immunostaining of the apical membranes and of granular Golgi like structures below the apical surface.

REFERENCE

There are currently no references for MUC1 antibody [MSVA-672R] HistoMAX™ (GTX04397). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for MUC1 antibody [MSVA-672R] HistoMAX™ (GTX04397). Be the first to share your experience with this product.
Package List Price ($)
$ 519
$ 299