PRODUCT
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Calculated MW
Positive Control
Lung: A strong staining should be seen in endothelial cells, and at least a weak to moderate membranous CD141 staining should be seen in alveolar macrophages.
Negative Control
Colon: Kidney: Epithelial cells should not stain for CD141.
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fragment (around aa 69-194) of human Thrombomodulin (CD141) protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
thrombomodulin , AHUS6 , BDCA3 , CD141 , THPH12 , THRM , TM
Cellular Localization
Membrane; Single-pass type I membrane protein
Background
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/templates/default/js/lightbox/images/loading.gif "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
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GTX04446 IHC-P Image
IHC-P analysis of human Ileum Neuroendocrine tumor tissue section using GTX04446 Thrombomodulin antibody [MSVA-141M] HistoMAX.
Neuroendocrine tumor with strong CDH17 immunostaining of all tumor cells CDH17 immunohistochemistry.
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GTX04446 IHC-P Image
IHC-P analysis of human Colorectal adenocarcinoma tissue section using GTX04446 Thrombomodulin antibody [MSVA-141M] HistoMAX.
Colorectal adenocarcinoma with strong CDH17 immunostaining of all tumor cells CDH17 immunohistochemistry.
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GTX04446 IHC-P Image
IHC-P analysis of human Rectum mucosa tissue section using GTX04446 Thrombomodulin antibody [MSVA-141M] HistoMAX.
A strong membranous CDH17 staining occurs in all epithelial cells of the rectum mucosa CDH17 immunohistochemistry.
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REFERENCE
There are currently no references for Thrombomodulin antibody [MSVA-141M] HistoMAX™ (GTX04446). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Thrombomodulin antibody [MSVA-141M] HistoMAX™ (GTX04446). Be the first to share your experience with this product.
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/small/GTX04446/GTX04446_20230728_IHC-P_392_23072723_541.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/small/GTX04446/GTX04446_20230728_IHC-P_391_23072723_183.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/small/GTX04446/GTX04446_20230728_IHC-P_393_23072723_982.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/normal/GTX04446/GTX04446_20230728_IHC-P_392_23072723_541.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/normal/GTX04446/GTX04446_20230728_IHC-P_391_23072723_183.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")
![Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446](/upload/website/prouct_img/normal/GTX04446/GTX04446_20230728_IHC-P_393_23072723_982.webp "Anti-Thrombomodulin antibody [MSVA-141M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04446")