APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
Not tested in other applications.
Predict Reactivity
Mouse, Rat, Zebrafish, Dog, Pig, Xenopus tropicalis, Chimpanzee, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 2% BSA
Preservative
0.025% ProClin 300
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent
Antigen Species
Human
Immunogen
Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
thymidylate synthetase ,HST422 ,TMS ,TS
Cellular Localization
Nucleus,Cytoplasm,Mitochondrion,Mitochondrion matrix,Mitochondrion inner membrane
Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/templates/default/js/lightbox/images/loading.gif "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
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GTX639929 IHC-P Image
IHC-P analysis of human urinary bladder tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Muscle-invasive urothelial carcinoma with moderate to strong TYMS staining of most tumor cells.
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GTX639929 IHC-P Image
IHC-P analysis of human thymus tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Strong TYMS staining of a large fraction of lymphocytes.
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GTX639929 IHC-P Image
IHC-P analysis of human spleen tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Moderate to strong TYMS staining of a fraction of lymphocytic cells.
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REFERENCE
There are currently no references for Thymidylate synthase antibody [HMV305] HistoMAX™ (GTX639929). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Thymidylate synthase antibody [HMV305] HistoMAX™ (GTX639929). Be the first to share your experience with this product.
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_2_24040301_930.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_24040301_377.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_1_24040301_669.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_2_24040301_930.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_24040301_377.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_1_24040301_669.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")