GTX62437 is currently not offered.

Summary This antibody is raised against a common region among splicing variants in the cytoplasmic tail domain (CTD) of MUC1-C. Therefore, it is possible to detect various splicing variants, regardless of MUC-1's structure of extracellular region.

Summary Multiple isoforms of MUC1 are known to exist. MUC1 often migrates at a higher molecular weight in SDS-PAGE due to high levels of post-translational modification.

Summary In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This MAb reacts with the DTRP epitope in the tandem repeats.

Summary Reacts with an antigen of 265-400 kD belonging to a heterogeneous group of heavily glycosylated proteins called human milk fat globule proteins. It stains both normal and neoplastic cells. Among normal epithelia, it reacts strongly with mammary epithelium and glandular epithelia but shows a patchy staining with squamous epithelium.

Summary This antibody recognizes the peptide epitope ARG-PRO-ALA-PRO within the protein core of the mucin.

Summary The dominant epitope of this antibody involves both amino acids as well as sugar moieties. Its epitope is destroyed by desialylation i.e. treatment with Neuraminidase.