beta Amyloid

 

Conformation-specific beta-Amyloid antibody for Alzheimer's disease research

Alzheimer’s disease (AD) pathogenesis is widely believed to be driven by the production and deposition of neurotoxic β-Amyloid peptide (Aβ) aggregates that form plaques in the brain. The Aβ molecules are generated from Amyloid Precursor Protein (APP) via β- and γ- secretase cleavage to produce Aβ monomers. Most of the Aβ peptides are 40 amino acids in length (Aβ 1-40, Aβ40), with a small percentage containing 42 residues (Aβ 1-42, Aβ42). These additional two C-terminal amino acids in Aβ42 confer a greater tendency to misfold and subsequently aggregate. Thus, Aβ42 is considered to be more neurotoxic than Aβ40.

 

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510, Rabbit pAb) and (GTX635160, mouse mAb)” against Aβ 1-42 oligomers can specifically detect amyloid plaques in the AD brain by IHC-P analysis. The superior specificity and sensitivity of GTX134510 and GTX635160 were confirmed by dot blot and side-by-side IHC-P comparison.

 

Featured Products

  • Human Aβ (1-42) oligomer immunogen
  • Human Aβ (1-42) oligomer immunogen  • Validated for dot blot, IHC-P, and ELISA
  • High affinity and specificity
  • Low background staining
  • Detects beta-Amyloid aggregates in human AD brain tissue by IHC-P
  • Detects beta-Amyloid aggregates in mouse AD model brain tissue by IHC-P

     

beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510)

 

Dot blot analysis of beta-Amyloid peptide (1-42) oligomers or monomers, using beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510)

GTX134510

beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in occipital lobe tissue from a brain with Alzheimer's disease, but not in normal human brain tissue.

GTX134510

beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in hippocampal tissue from a 3xTg-AD transgenic mouse brain.

GTX134510

 

Side-by-side IHC-P comparison of two conformation-specific beta-Amyloid antibodies in occipital lobe of human brains with Alzheimer's disease (1:500 dilution). Only GeneTex’s beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) is able to detect beta-Amyloid plaques in the samples.

GTX134510

       

Beta amyloid (1-42) antibody – Conformation Specific antibody [GT622] (GTX635160)

 

Beta amyloid (1-42) antibody – Conformation Specific antibody [GT622]_1

Dot blot analysis of beta-Amyloid peptide (1-42) oligomers or monomers, using beta Amyloid (1-42) antibody – Conformation Specific [GT622]

GTX635160

beta-Amyloid (1-42) antibody – Conformation Specific [GT622] (GTX635160) detects beta-Amyloid plaques by IHC-P analysis in hippocampal tissue from a 3xTg-AD transgenic mouse brain (left) but not in an age-matched healthy mouse brain (right).

GTX635160

Sandwich ELISA detection of beta-Amyloid (1-42) peptide aggregates using GTX635160 as capture antibody at concentration of 10 µg/mL and GTX134510 as detection antibody at concentration of 0.45 µg/mL.

GTX635160

GTX635160
Beta amyloid (1-42) antibody – Conformation Specific antibody_4[GT622]

beta-Amyloid (1-42) antibody – Conformation Specific [GT622] (GTX635160) detects beta-Amyloid plaques by IHC-P analysis in cerebellum tissue from a brain with Alzheimer's disease, but not in normal human brain tissue.

GTX635160