11250747

BRCA1 antibody [17F8] - ChIP grade GTX70111

References 27

KO/KD Orthogonal

Summary This antibody does not recognize the delta exon 11 splice variant of BRCA1. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm.

BRCA1 antibody [8F7] GTX70113

References 16

KO/KD

Summary This antibody recognizes full-length BRCA1, a 220-kDa nuclear phosphoprotein. Mutations in this tumor suppressor gene greatly increase the risk of breast cancer.
KO/KD validation is based on published data (PMID: 23805307).