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Summary This antibody recognizes an activation-dependent intracellular epitope of CD3 epsilon. Exposure of the epitope precedes CD3 phosphorylation and recruitment and activation of ZAP70, which initiates the signaling cascade produced by T-cell activation. APA1/1 provides the earliest known marker for TCR-mediated T cell activation.

Summary This antibody reacts with cK Ras and vK Ras, and cross-reacts with cH Ras or cN Ras p21s in immunoblotting. For this reason we recommend a sample concentration step prior to immunoblotting; concentrate to 5 μg/ml with 1% gelatin as a stabilizer. For immunoprecipitation, use 5 μg per sample with 45 μl protein A agarose.

Summary The monoclonal antibody 74.5.2 is directed against epitopes in the XC15 peptide that contains a binding site for high-molecular-weight kininogen and Factor XII. Clone 74.5.2 recognizes both the mature (74 – 282) and truncated form, lacking residues 74-95.

Summary May be used in monitoring for NGF (2.5S, β and 7S).