GeneTex
United States (US)

Epidermal Cells

Epidermal cells form the epidermis, the outermost of the three layers that together constitute the skin. Histologically, the epidermis is composed primarily of four tightly adherent layers of squamous epithelium organized into distinct vertical zones by stages of differentiation. From innermost to outermost, the layers are: stratum basale (basal cell layer), stratum spinosum (spinous layer), stratum granulosum (granular layer), and stratum corneum (cornified layer). The epidermis consists largely of keratinocytes (>90%) but also contains melanocytes, Langerhans cells, Merkel cells, and inflammatory cells.
GeneTex is proud to offer an outstanding selection of antibody reagents to study epidermal cells. Please see the highlighted antibodies below.

 

Hot Products
Citation Support 

CD1a antibody [C1A/711]
(GTX34471)

Filaggrin antibody
(GTX37695)

 

Cytokeratin 5 antibody
(GTX113219)

 

Cytokeratin 20 antibody [N2C2], Internal
(GTX110600)

 
     

 

Keratinocyte Markers
Citation Support KOKD Validation
Keratinocytes are the most abundant type of cell in the epidermis and are responsible for synthesizing keratin protein. They exist in progressive stages of differentiation from the basal layer of the epidermis to the superficial cornified layer.

 

Product Name Clonality Applications Reactivity Cat. No.  
Cytokeratin 2 antibody [N2C2], Internal Rb pAb IHC-P, WB Hu, Ms, Rat GTX102758
Cytokeratin 5 antibody Rb pAb IHC-P, WB Hu, Rat GTX113219
Cytokeratin 10 antibody Rb pAb IHC-P, WB Hu GTX113221  
Cytokeratin 10 antibody [VIK-10] Ms mAb IHC-P Hu, Ms, Rat GTX21421
Cytokeratin 14 antibody Rb pAb IHC-P Hu, Ms, Dog, Rat GTX104124
Cytokeratin 14 antibody [N3C3] Rb pAb IHC, IHC-Fr, IHC-P Hu GTX112976  
Cytokeratin 15 antibody Rb pAb IHC-P Hu GTX114517  
Cytokeratin 15 antibody Rb pAb FACS, ICC/IF, IHC-P, WB Hu, Dog, Mk, Rat GTX100572  
Envoplakin antibody Rb pAb IHC-P Hu, Hrs GTX64908  
Filaggrin antibody Rb pAb GSA, IHC-Fr, IHC-P, IP, WB Hu, Ms, Rat GTX37695
Filaggrin antibody [SPM181] Ms mAb WB Hu, Ms GTX34732
Involucrin antibody [N1N2], N-term Rb pAb IHC-P, WB Hu, Ms, Rat GTX116012
Involucrin antibody [SY5] Ms mAb ICC/IF, IHC-P, WB Hu GTX72415
Loricrin antibody Rb pAb ELISA, ICC/IF, IHC-P, IP, WB Hu, Ms, Pig, Rat, Bov GTX127943  
Loricrin antibody [N1], N-term Rb pAb ICC/IF, IHC, IHC-Fr, IHC-P Hu, Ms, Mk, Rat, Bov GTX116013
p63 antibody [N2C1], Internal Rb pAb ICC/IF, IHC-Fr, IHC-P, WB Hu, Ms, Rat GTX102425
pan Cytokeratin antibody [C-11] Ms mAb WB Hu GTX27753
Periplakin antibody [N1N2], N-term Rb pAb IHC-P Hu, Ms GTX117411  
TGM1 antibody Rb pAb ICC/IF, IHC-P, WB Hu GTX32921  
TGM3 antibody Rb pAb WB Hu GTX33543  
TGM5 antibody Rb pAb IHC-P, WB Hu GTX31459  

 

Melanocyte Markers
Citation Support
Melanocytes, located in the basal layer of the epidermis, produce melanin, a dark pigment that protects cells from ultraviolet radiation.

 

Product Name Clonality Applications Reactivity Cat. No.  
Endothelin B Receptor antibody Rb pAb ICC/IF, IHC-P, WB Hu GTX100357
Endothelin B Receptor antibody [C3], C-term Rb pAb ICC/IF, IHC-P, WB Hu, Ms GTX108204
Endothelin B Receptor antibody [N1N2], N-term Rb pAb WB Hu GTX100356  
Melan A antibody [M2-9E3] Ms pAb ICC/IF, IHC-P, IP Hu GTX34826  
Melan A antibody [MLANA/788] Ms mAb IHC-Fr, ICC/IF, IHC, WB, IHC-P Hu, Rat GTX34829  
Melanoma antibody [HMB45] Ms pAb IHC-P, WB Hu GTX20787
Melanoma antibody [PNL2] Ms mAb IHC-P, WB Hu GTX12502  
Melanoma gp100 antibody [10E5] Ms pAb IHC-P, WB Hu GTX83638  
Melanoma gp100 antibody [NKI-beteb] Ms pAb WB Hu, Ms, Rat GTX34835  
MITF antibody [C5] Ms mAb IHC-P, WB Ms, Rat GTX12039
MITF antibody [N2C1], Internal Rb mAb IHC-P Hu GTX113776
PTGDS antibody Rb mAb ICC/IF, IHC-P, WB Hu GTX55765  
S100 alpha 2 antibody [N1C3] Rb mAb ELISA, ICC/IF, IHC-Fr, IHC-P Hu, Dog, Mk, Pig, Rat, Glla, Owl GTX121457
S100 alpha antibody Rb pAb ICC/IF, WB Hu GTX11428
S100 antibody [4C4.9] Ms pAb ICC/IF, IHC-P, WB Hu GTX24066
S100 beta antibody Ms pAb ICC/IF, IHC-Fr, IHC-P, IP, WB, PLA Hu, Ms, Rat GTX129573
SLC45A2 antibody, C-term Rb mAb FACS, ICC/IF, IHC-P, IP, WB Hu, Ms, Mamm GTX46854  
TRP1 antibody [TYRP1/807] Ms pAb IHC-P, WB Hu, Ms GTX35149  
TRP2 antibody Rb mAb IHC-P, WB Hu GTX56299  
Tyrosinase antibody [N3C3] Rb mAb ICC/IF, IHC, WB Hu, Ms, Rat GTX101094  
Tyrosinase antibody [T311] Ms mAb ELISA, IHC-P, WB Hu, Ms, Rat GTX20738

 

Langerhans Cell Marker
Citation Support
Langerhans cells are specialized phagocytic macrophage-like antigen-presenting cells (APCs) that represent 3% of the epidermal cell population. They drive protective immune responses through interactions with lymphocytes during skin infections.

 

Product Name Clonality Applications Reactivity Cat. No.  
CD1a antibody [7A7] Ms mAb ELISA, ICC/IF, IHC-P, WB Hu GTX60418  
CD1a antibody [C1A/711] Ms mAb IHC-P Hu GTX34471  
CD1a antibody [NA1/34-HLK] Ms mAb FACS, IHC-Fr Hu, Dog, ClMK GTX76536  
CD4 antibody [GK1.5] Rat mAb ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB Ms GTX44531
HLA-DR  antibody [N2C3] Rb pAb IHC-P, WB Hu GTX113459
HLA-DR1 antibody [MEM-267] Ms mAb ELISA, FACS, WB Hu GTX78393
HLA-DRA antibody [N2C3] Rb pAb ICC/IF, IHC-P, WB Hu GTX113732  
HLA-DRB1 antibody [N1C3] Rb pAb WB, IHC-P Hu GTX104919
HLA-DRB3 antibody Rb pAb ICC/IF Hu GTX105068  
HLA-DRB5 antibody Rb pAb WB Hu GTX131196  
Langerin antibody [N2C3] Rb pAb WB Hu, Ms GTX116461  

 

Merkel Cell Markers
Citation Support KOKD Validation
Merkel cells, located in the basal layer of the epidermis, are oval-shaped mechanosensitive cells involved in light touch sensation. The Merkel cell membrane interacts with somatosensory nerve endings in the skin through synapse-like connections.

 

Product Name Clonality Applications Reactivity Cat. No.  
Cytokeratin 20 antibody [N2C2], Internal Rb pAb ICC/IF, IHC-P, WB Hu, Ms GTX110600
Cytokeratin 18  antibody [N2C2], Internal Rb pAb ICC/IF, IHC-P, IP, WB Hu, Ms GTX105624
Cytokeratin 18 antibody [N1N3] Rb pAb ICC/IF, IHC-P, WB Hu GTX112977
Cytokeratin 8 antibody [N1C1] Ms mAb ICC/IF, IHC-P, WB Hu, Ms, Rat GTX112975
Cytokeratin 8 antibody Rb pAb ICC/IF, IHC-P, WB Hu, Ms GTX110311
MATH1 antibody [C2C3], C-term Rb pAb IHC-P Ms GTX111898  

 

Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.