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Histone Modifications

Histone Modifications

The nucleosome core particle is the fundamental structural unit of the eukaryotic genome. It consists of a histone octamer composed of two H2A-H2B dimers and a H3-H4 tetramer wrapped by ~146 base pairs of DNA. A linker histone (i.e., H1) associates with the nucleosomal dyad as well as with linker DNA on either side of the nucleosome, resulting in the formation of the chromatosome. All the core and linker histones are post-translationally decorated, with at least 160 total modifications described to date including acetylation, methylation, phosphorylation, propionylation, citrullination, formylation, proline isomerization, butyrylation, ADP ribosylation, ubiquitylation, sumoylation, and the more recently identified glycosylation and crotonylation. These modifications are thought to impact chromatin functions by either altering chromatin packaging or through the recruitment/inhibition of specific chromatin binding factors. Thus, the combined signal from a particular collection of histone marks constitutes a “histone code” that affects gene expression or other chromatin-based functions.

Highlighted Products

     

Histone H1 Antibodies

Histone H1.0 antibody (GTX114462)

 
Histone H1.2 antibody (GTX122561)

Histone H1.2 antibody (GTX122561)

 
Histone H1S35ph (phospho Ser35) antibody (GTX121669)

Histone H1S35ph (phospho Ser35) antibody (GTX121669)

 

Histone H2A Antibodies

https://www.genetex.com/Product/Detail/Histone-H2A-antibody/GTX129418

Histone H2A antibody (GTX129418)

Histone H2A.X antibody (GTX108272)

Histone H2A.X antibody (GTX108272)

 
Histone H2A.X (phospho Ser139) antibody (GTX628789)

Histone H2A.X (phospho Ser139) antibody (GTX628789)

 
 

Histone H2B Antibodies

Histone H2B antibody (GTX115955)

Histone H2B antibody (GTX115955)

 
Histone H2BK5ac (acetyl Lys5) antibody (GTX128963)

Histone H2BK5ac (acetyl Lys5) antibody (GTX128963)

Histone H2BK20ac (acetyl Lys20) antibody (GTX633409)

Histone H2BK20ac (acetyl Lys20) antibody (GTX633409)

 
 

 

Histone H3 Antibodies

Histone H3 antibody (GTX122148)

Histone H3 antibody (GTX122148)

 
Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915)

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

Histone H3K27me3 (Tri-methyl Lys27) antibody (GTX121184)

 
 

 

Histone H4 Antibodies

Histone H4 antibody (GTX129560)

Histone H4 antibody (GTX129560)

 
Histone H4K5K8K12K16ac (acetyl Lys5/Lys8/Lys12/Lys16) antibody (GTX122653)

Histone H4K5K8K12K16ac (acetyl Lys5/Lys8/Lys12/Lys16) antibody (GTX122653)

Histone H4K20me2 (dimethyl Lys20) antibody (GTX630545)

Histone H4K20me2 (dimethyl Lys20) antibody (GTX630545)

 
 

Histone Modifying Enzyme Antibodies

G9a antibody (GTX128164)

G9a antibody (GTX128164)

SUV39H1 antibody (GTX112263)

SUV39H1 antibody (GTX112263)

PRMT1 antibody (GTX630187)

 
HDAC1 antibody

HDAC1 antibody (GTX100513)

HDAC2 antibody

HDAC2 antibody (GTX109642)

HDAC3 antibody

HDAC3 antibody (GTX109679)

 
 
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Epigenetics poster

Poster - Epigenetics

Download the latest version of GeneTex's Epigenetics poster
Literature

Flyer - Epigenetics Histone Modification

Download the latest version of GeneTex's epigenetics histone modification flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Epigenetics poster

Poster - Epigenetics

Download the latest version of GeneTex's Epigenetics poster
Literature

Flyer - Epigenetics Histone Modification

Download the latest version of GeneTex's epigenetics histone modification flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.