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Summary Binding specificity was confirmed in peptide inhibition studies with the intact protein. The antibody does not recognize the native estrogen receptor in the inactive 8S oligomeric state, but reacts efficiently with the activated 4S receptor. In immunoprecipitation studies, this antibody has been shown to only IP the active receptor.

Summary This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53.
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