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Summary The antiserum is directed against the extracellular domain of the human IL-1R type I, but precipitates the intact receptor expressed on human cells. The antibody does not recognize human IL-1, IL-1Ra or IL-1R type II. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the IL-1R type I (also called soluble IL-1R type I or ''decoy'' receptor) found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid.

Summary Recognizes human and monkey LAG-3.

Summary Clone CC320 has been shown to neutralize the activity of bovine IL-10 as measured by the inhibition of the inhibitory activity of IL-10 on IFN gamma synthesis (Buza et al. 2004).

Summary Binds both glycosylated and non-glycosylated protein.

Summary Clone AK7 inhibits cell attachment to collagen.

Summary The CRA1 (AER37) monoclonal antibody reacts with the Fc epsilon R1 alpha subunit on a region that does not overlap the region of the IgE binding site, thus it does not compete withIgE for the receptor binding. Since the CRA2 (AER24) monoclonal antibody reacts with the IgE binding site on Fc epsilon R1 alpha, it competes with IgE for the receptor binding. Combining the two antibodies, one can quantitatively measure the amounts of the IgE-bound Fc epsilon R1 alpha.

Summary The antibody inhibits the biological activity of human native and recombinant IL-6 as determined with the B9 cell bioassay.