Human Papillomavirus (HPV)

Human papillomaviruses (HPV) infect differentiating squamous epithelium of the skin and mucous membranes. These viruses are categorized into high-risk or low-risk strains depending on their pathogenicity and carcinogenic risk. High-risk HPV strains account for approximately 5% of all human cancers and are associated with cervical, anogenital (anal, vulvar, vaginal, and penile), and head and neck cancers. Most notably, two specific high-risk types, HPV16 and HPV18, are responsible for roughly 70% of all cervical cancer cases worldwide.

 

HPV belongs to the Papillomaviridae family of small, non-enveloped, circular double-stranded DNA viruses with a genome size of approximately 7-8 kb. The genome is segmented into an upstream regulatory region (URR), an intergenic noncoding region (NCR), and eight primary ORFs coding for the early (E) and late (L) proteins. The early region encodes the non-structural proteins E1, E2, E4 (E1ˆE4), E5, E6, E7, and E8 (E8ˆE2), while the late region encodes the two capsid proteins L1 and L2. The E6 and E7 proteins, classified as oncoproteins, promote and maintain cancers by fostering cell proliferation, hindering apoptosis, undermining immune surveillance, promoting cell invasion, and disrupting the balance of cellular metabolism. E5 functions as an accessory oncoprotein.

 

 

To support HPV research, GeneTex provides a comprehensive catalog of highly validated antibodies targeting critical HPV antigens. These antibodies are optimized to deliver high sensitivity and specificity across a wide range of analytical platforms, including WB, ICC/IF, ELISA, and LFA.

 

 

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 Human Papillomavirus type 16 (HPV16)

 

Human Papillomavirus type 16 E7 antibody [HL1647] GTX637228	Human Papillomavirus type 16 E7 antibody [HL1821] GTX637546	Human Papillomavirus type 16 E7 antibody GTX133411	Human Papillomavirus type 16 E7 protein, His tag GTX133411-pro

 

 

 

Product Name Cat. No. Host and  Clonality Reactivity Applications Human Papillomavirus type 16 E6 antibody GTX132686 Rb pAb HPV16 WB Human Papillomavirus type 16 E7 antibody [HL1647] GTX637228 Rec Rb mAb HPV16 ELISA, ICC/IF, Lateral Flow, Sandwich ELISA Human Papillomavirus type 16 E7 antibody [HL1821] GTX637546 Rec Rb mAb HPV16 ELISA, Lateral Flow, Sandwich ELISA, WB Human Papillomavirus type 16 E7 antibody GTX133411 Rb pAb HPV16 WB Human Papillomavirus type 16 E7 protein, His tag GTX133411-pro     ELISA, Lateral Flow, Sandwich ELISA

 

 

 

 

Human Papillomavirus type 18 (HPV18)

 

Human Papillomavirus type 18 E7 antibody [HL2522] GTX638883	Human Papillomavirus type 18 E7 antibody [HL2789] GTX639657	Human Papillomavirus type 18 E7 antibody [HL2787] GTX639655	Human Papillomavirus type 18 E7 protein, His tag GTX133412-pro

 

 

 

 

Product Name Cat. No. Host and  Clonality Reactivity Applications Human Papillomavirus type 18 E2 antibody GTX133373 Rb pAb HPV18 WB Human Papillomavirus type 18 E6 antibody GTX132687 Rb pAb HPV18 WB Human Papillomavirus type 18 E7 antibody [GT881] GTX634337 Ms mAb HPV18 ELISA, ICC/IF, Lateral Flow, Sandwich ELISA, WB Human Papillomavirus type 18 E7 antibody [HL2522] GTX638883 Rec Rb mAb HPV18 ELISA, Lateral Flow, Sandwich ELISA, WB Human Papillomavirus type 18 E7 antibody [HL2787] GTX639655 Rec Rb mAb HPV18 WB Human Papillomavirus type 18 E7 antibody [HL2788] GTX639656 Rec Rb mAb HPV18 Lateral Flow, WB Human Papillomavirus type 18 E7 antibody [HL2789] GTX639657 Rec Rb mAb HPV18 ELISA, Lateral Flow, WB Human Papillomavirus type 18 E7 antibody GTX133412 Rb pAb HPV18 ICC/IF, WB Human Papillomavirus type 18 E7 protein, His tag GTX133412-pro     ELISA, Lateral Flow, Sandwich ELISA

 

 

References:

Cancers (Basel). 2026 Jan 20;18(2):318.

Structure. 2024 Nov 7;32(11):1877-1892.

Trends Mol Med. 2024 Sep;30(9):890-902.