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Summary Inter-species cross-reactivity is a normal feature of antibodies to mammalian proteins, since homologous proteins of different species frequently share antigenic determinants. The degree of cross-reactivity is also dependent on the concentRations of the reactants and the sensitivity of the assay arrangement. This antiSerum fraction has not been tested for cross-reactivity.

Summary The monoclonal antibody 18D11 reacts with both soluble and membrane CD14. The monoclonal antibody 18D11 is useful for inhibition of biological activity of sCD14, it inhibits LPS induced TNF production. Together with a C5a neutralizing monoclonal antibody, 18D11 blocks sepsis in a pig model.

Summary Reacts weakly with alpha-HRG and strongly with beta-HRG. Does not inhibit the binding of HRG to ErbB receptors but it efficiently blocks the HRG-induced proliferation and differentiation of cultured human mammary cells.

Summary This antibody is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as plasmacytoid T cells.