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Summary This MAb reacts with a 200kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase, this Ab no longer binds.

Summary This antibody can detect over-expressed melanopsin protein but it does not work well on endogenously expressed protein.

Summary Screening was performed by ELISA using the immunogen, followed by immunofluorescence microscopy. Clones which revealed strong staining were further characterized biochemically.

Summary This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C. And it may have minor crossreactivity to PDE4D.

Summary Epitope mapping studies suggest that this antibody binds a portion of GAP that contains the src homology regions SH2 and SH3.