Search Results

Summary This antibody is raised against mouse c-Abl (isoform b) phosphorylated at Tyr412. Based on sequence homology, it is predicted to react with c-Abl (isoform a) and ABL2 when phosphorylated at the corresponding residues - c-Abl (isoform a) Tyr393 and ABL2 Tyr439.

Summary This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein.The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

Summary This antibody is raised against human c-Abl (isoform b) phosphorylated at Tyr412. Based on sequence homology, it is predicted to react with c-Abl (isoform a) or ABL2 when phosphorylated at the corresponding residues - c-Abl (isoform a) Tyr393 or ABL2 Tyr439.