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Summary This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity of this antibody for IR by approximately 100 fold. This antibody reacts with autophosphorylated IR, unoccupied IR, and the insulin IR complex. It has no effect on insulin-stimulated autophosphorylation.

Summary This antibody stains the extracellular domain of beta-1 integrin. The monoclonal antibody BV7 does not recognize α5β1 complex and not the cytoplasmic part of theβ1-subunit. Monoclonal antibody BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells.

Summary This antibody recognizes the extracellular domain of CD120a. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

Summary This antibody reacts with ERK1 p44 and to a lesser extent ERK2 p42.