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Summary The full-length EGFR includes the 24 aa signal peptide that is cleaved during EGFR maturation. The Tyr1173 of mature EGFR is equivalent to Tyr1197 of uncleaved EGFR.

Summary The epitope recognized by clone 2H7 has been mapped to the following sequence found in the large extracellular loop of human CD20: YNCEPANPSEKNSPST. Furthermore it appears that Mouse anti Human CD20 antibody, clone 2H7 only recognizes human CD20 in its native oligomeric form (Polyak et al. 2002).

Summary This antibody is raised against a common region among splicing variants in the cytoplasmic tail domain (CTD) of MUC1-C. Therefore, it is possible to detect various splicing variants, regardless of MUC-1's structure of extracellular region.

Summary Its epitope is resistant to digestion by trypsin and chymotrypsin. This antibody selectively interferes with lymphocyte binding to lymph node, mucosal and synovial endothelium.