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Summary The antibody is specific for the p35 subunit of IL-12 p70 heterodimer (p40 +p35). In combination with C17.8 (p40 specific), it is able to detect native and recombinant mouse IL-12 p70 and recognizes the p35 subunit of IL-12 p70 heterodimer (p40 + p35).

Summary This antibody is able to detect native and recombinant human IL-1帣, binds to the pro-form and active form of IL-1帣, and has no cross-reactivity with IL-1帢.

Summary This antibody is able to detect native and recombinant mouse IL-6.

Summary This antibody is able to detect native and recombinant human IL-13.

Summary This antibody is able to detect native and recombinant mouse p40 subunit of IL-12 and IL-23. In combination with different detection antibodies, it is able to recognize p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40 + p35), and IL-23 heterodimer (p40 + p19).

Summary This antibody is able to detect native and recombinant mouse TNF-帢.

Summary This antibody recognizes a conformationally-dependent epitope of CD8. The antibody does not react with formaldehyde-fixed cells; negative in Western blotting application.

Summary The YTS 177 antibody has been shown to compete with clones GK1.5 and YTS 191 for CD4 binding. The YTS 177 antibody has been reported to be non-depleting but binding does induce rapid internalization of CD4 on both CD4+ Foxp3- T cells and Foxp3+ regulatory T cells. Further, the YTS 177 clone has been shown to suppress or even prevent allograft rejection, allergic reactions and autoimmune responses.