Apoptosis

Apoptosis is programmed cell death and is crucial for development and tissue homeostasis. It can be initiated by various stimuli and can progress through a receptor-mediated extrinsic pathway or an intrinsic pathway that starts with mitochondrial events. Both processes involve the activation of caspases. Apoptotic cells undergo distinct changes in cell morphology such as cell rounding, plasma membrane blebbing, and nuclear fragmentation. A spectrum of key players is involved, including transcription factors such as the tumor suppressor p53 and FOXO3a that drive expression of pro-apoptotic genes, effectors such as Caspase 3 and ROCK1, and factors like PARP and AIF that function in a caspase-independent pathway.

PARP antibody [N2C1], Internal GTX112864	Caspase 3 antibody GTX110543	Annexin A1 antibody GTX101070	Caspase 7 antibody GTX123679

CDKN2A / p14ARF antibody GTX129903	TNF alpha antibody GTX110520