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Virus Entry

Infection by animal viruses is initiated by viral binding to host cells. Delineation of the mechanisms mediating subsequent viral entry is an area of intense research, as there is considerable complexity and variability among different viruses. Nevertheless, a general framework for this process, particularly for some enveloped viruses, involves the following steps: (1) viral attachment to host cell receptors, (2) cell signaling pathway activation, (3) endocytosis, (4) penetration of cellular membranes and intracellular trafficking, and (5) viral genome uncoating. The viral genome is then available for expression, replication, packaging and release to infect other cells. Understanding the molecular events underlying virus/host cell interactions during entry is of paramount importance for the potential identification of targets for pharmacologic intervention.

GeneTex is proud to offer an outstanding selection of antibodies to study virus attachment, internalization and penetration for infectious disease research. These antibodies are validated for various applications to facilitate your efforts in this exciting field. Please see the highlighted products below or go to our website (www.genetex.com).

Highlighted Products
   
ACE2 antibody [N1N2], N-term (GTX101395)

ACE2 antibody [N1N2], N-term (GTX101395)

TMPRSS2 antibody [N2C3] (GTX100743)

TMPRSS2 antibody [N2C3] (GTX100743)

 
AXL antibody (GTX129407)

AXL antibody
(GTX129407)

CD13 antibody (GTX102788)

CD13 antibody
(GTX102788)

ICAM1 / CD54 antibody [N1C2] (GTX100450)

ICAM1 / CD54 antibody [N1C2] (GTX100450)

Occludin antibody (GTX114949)

Occludin antibody
(GTX114949)

 

Newsletter
GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry

GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry

GeneTex’s SARS-CoV-2 Spike RBD Antibodies Effectively Inhibit Viral Entry
Newsletter

Neuropilins Facilitate SARS-CoV-2 Entry into Host Cells

Neuropilins Facilitate SARS-CoV-2 Entry into Host Cells
Literature
Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

SARS-CoV-2 (COVID-19) Research Reagents
Newsletter

Zika Virus Infection Increases Risk of Subsequent Severe Dengue Disease

Zika Virus Infection Increases Risk of Subsequent Severe Dengue Disease
Literature
Brochure - SARS-CoV-2 (COVID-19) Research

Brochure - SARS-CoV-2 (COVID-19) Research

Download the latest version of GeneTex's SARS-CoV-2 (COVID-19) Research brochure.
Newsletter
IHC- and FCM-validated Antibodies for SARS-CoV-2 Research

IHC- and FCM-validated Antibodies for SARS-CoV-2 Research

IHC- and FCM-validated Antibodies for SARS-CoV-2 Research
Newsletter
Spike Antibody-mediated Neutralization of SARS-CoV-2

Spike Antibody-mediated Neutralization of SARS-CoV-2

Spike Antibody-mediated Neutralization of SARS-CoV-2
Articles
SARS-CoV-2 Webinar: A World Problem Needing a World Response

GeneTex Webinar: SARS-CoV-2 and COVID-19

A World Problem Needing a World Response
Articles

The concept of a SARS-CoV-2 / COVID-19 rapid test

A rapid virus antigen test detects SARS-CoV-2 particles in samples by capturing viral antigen between a free labeled antibody and a fixed second antibody that each recognize different regions of the antigen.
Literature

Flyer - Virus Entry into Host Cells

Download the latest version of GeneTex's Virus entry into host cells flyer.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Literature
Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

Pamphlet - SARS-CoV-2 (COVID-19) Research Reagents

SARS-CoV-2 (COVID-19) Research Reagents
Literature
Brochure - SARS-CoV-2 (COVID-19) Research

Brochure - SARS-CoV-2 (COVID-19) Research

Download the latest version of GeneTex's SARS-CoV-2 (COVID-19) Research brochure.
Literature

Flyer - Virus Entry into Host Cells

Download the latest version of GeneTex's Virus entry into host cells flyer.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.