| Neurites are projections from the neuronal cell body that develop into axons and dendrites to form complex neuronal circuits. These circuits are highly dynamic, with ongoing reconfiguration and refinement characteristic of the structural plasticity necessary for learning and memory. Neurite outgrowth also occurs during nerve regeneration. Chemical synapse communication is defined by the release of neurotransmitters from the pre-synaptic neuron with binding to receptors on the post-synaptic neuron. Synaptic degeneration is evident in the course of neurodegenerative disease, though the underlying mechanisms are poorly understood. To facilitate study of neurite and synapse biology, antibodies detecting neuron-specific and pre- and postsynaptic markers are essential tools for neuroscience researchers. |
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