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Neuroinflammation

Neuroinflammation

Neuroinflammation

Neuroinflammation occurs within the central nervous system (CNS) as a result of infection, injury, autoimmune processes, or toxicity. Microglia, as the specialized resident macrophage cells in the CNS, play crucial roles in both the initiation and resolution of neuroinflammation. However, their impact on neurons is complex. Microglia demonstrate a phenotypic plasticity that is directly influenced by the regional brain microenvironment. Thus, the M1/M2 dichotomy labeling used to describe other macrophage activity is inadequate to reflect the true heterogeneity of the microglial population. It is known that in neurodegenerative disease the microglia may display a “disease-associated microglia signature” that involves expression of genes found in both M1 and M2 profiles. Therefore, though important for the initial response to neuronal insult, microglia often contribute to the neuronal loss characteristic of these diseases.

GeneTex is proud to offer an outstanding, well-cited Iba1 antibody (GTX101495) as an important addition to your reagent collection for microglia research. This antibody was validated in part through side-by-side comparison with other market-leading antibodies for western blot and immunohistochemistry (Fig. 1 and Fig. 2) *.

Iba1 antibody

Fig. 1. Western blot of THP-1 and HL-60 whole cell extracts probed with GeneTex Iba1 antibody (GTX101495) or competitors’ antibodies.

Iba1 antibody

Fig. 2. IHC analysis staining microglial cells in mouse cerebellum sections with either GeneTex Iba1 antibody (GTX101495) or competitor’s antibody.

  

For more antibodies to study neuroinflammation, please see the featured products below or click here to view the complete list.

Featured Products

 Citation Support KO/KD Comparable-Abs Orthogonal Validation Protein Overexpression 
Iba1 antibody

Iba1 antibody
(GTX101495)

Citation Support Orthogonal Validation
TMEM119 antibody

TMEM119 antibody
(GTX134087)

CD11b antibody

CD11b antibody
(GTX134493)

CD163 antibody [EDHu-1]

CD163 antibody [EDHu-1]
(GTX42365)

IL1 beta antibody

IL1 beta antibody
(GTX74034)

Citation Support Orthogonal Validation
IL10 antibody

IL10 antibody
(GTX130513)

  

*Competitors are not affiliated with GeneTex and do not endorse this product.

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World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
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Neuroinflammation

Flyer - Neuroinflammation

Download the latest version of GeneTex's Neuroinflammation flyer.
Literature
Neurotransmission

Flyer - Neurotransmission

Download the latest version of GeneTex's Neurotransmission flyer.
Literature
Recombinant Active Proteins

Flyer - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins flyer.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Neuroinflammation

Flyer - Neuroinflammation

Download the latest version of GeneTex's Neuroinflammation flyer.