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Summary The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. The antibody is a agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.

Summary This antibody stains the extracellular domain of beta-1 integrin. The monoclonal antibody BV7 does not recognize α5β1 complex and not the cytoplasmic part of theβ1-subunit. Monoclonal antibody BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells.

Summary We do not recommend use of this product for Dog.

Summary Recognizes human phosphorylated tyrosine residues. Does not crossreact with phosphorylated threonine or phosphorylated serine residues. Binding to phosphorylated tyrosine residues is inhibited by divalent cations at concentrations >1mM and salt concentrations >0.2M.

Summary Detects recombinant and endogenous Nup153 in human, rat & Xenopus