Angiogenesis

Angiogenesis entails the generation of new blood vessels from pre-existing vasculature. It is an intricate process tightly regulated by input from pro- and anti-angiogenic factors. In the normal adult, the balance between these inducers and inhibitors maintains a quiescent state that nevertheless is capable of rapid changes in response to micro-environmental disruptions secondary to wounds, hypoxia, or inflammation. Perturbations of this balance in various chronic pathological conditions and tumors can lead to inappropriate angiogenesis or neovascularization.

The mechanistic features underlying angiogenesis are complex, but the clinical importance of being able to modulate this process means that this will remain a compelling and dynamic field of research.

Highlighted Products

VEGF antibody (GTX102643)

VEGF antibody [VG1] (GTX21316)

VEGF Receptor 2 antibody (GTX129943)

Angiopoietin 2 antibody (GTX100928)

TIE1 antibody (GTX107818)

TIE2 antibody (GTX107505)

Cat. No.	Product Name	Host & Clonality	Reactivity	Applications
GTX102643	VEGF antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX129844	VEGF antibody	Rb pAb	Hu	WB
GTX74091	VEGF antibody	Rb pAb	Ms	ELISA, ICC/IF, IHC-P, WB, Functional Assay
GTX21316	VEGF antibody [VG1]	Ms mAb	Hu, Ms, Rat	ELISA, ICC/IF, IHC-Fr, IHC-P, WB
GTX16404	VEGFB antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX113574	VEGFC antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX59914	VEGFC antibody	Rb pAb	Hu	WB
GTX100805	VEGFD antibody [N3C3]	Rb pAb	Hu	IHC-P, WB
GTX113695	VEGFD antibody	Rb pAb	Hu	IHC-P, WB
GTX128969	VEGF Receptor 1 antibody	Rb pAb	Hu	WB
GTX22350	VEGF Receptor 1 antibody	Rb pAb	Hu, Ms, Rat	IHC, IHC-Fr, IHC-P
GTX32184	VEGF Receptor 1 (phospho Tyr1213) antibody	Rb pAb	Hu, Rat	WB
GTX129943	VEGF Receptor 2 antibody	Rb pAb	Hu	WB
GTX17530	VEGF Receptor 2 antibody	Chk pAb	Hu, Ms, Rat, Bov	IHC, WB
GTX50432	VEGF Receptor 2 antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
GTX50153	VEGF Receptor 2 (phospho Tyr951) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
GTX25473	VEGF Receptor 2 (phospho Tyr1054/Tyr1059) antibody	Rb pAb	Hu, Ms	FACS, ICC/IF, WB
GTX32403	VEGF Receptor 2 (phospho Tyr1175) antibody	Rb pAb	Hu, Ms	ICC/IF, IHC-P, WB
GTX100807	VEGF Receptor 3 antibody	Rb pAb	Hu, Ms	WB
GTX17567	VEGF Receptor 3 antibody [818CT12.1.1]	Ms mAb	Hu, Rat	FACS, IHC-P, WB
GTX107818	TIE1 antibody	Rb pAb	Hu, Ms	IHC-P, WB
GTX103429	TIE1 antibody	Rb pAb	Hu	IHC-P, WB
GTX107505	TIE2 antibody	Rb pAb	Hu	IHC-P, WB
GTX107838	TIE2 antibody [C1C3]	Rb pAb	Hu, Ms	IHC-P, WB
GTX55336	TIE2 (phospho Tyr992) antibody	Rb pAb	Hu	WB
GTX121937	AKT antibody [N3C2], Internal	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
GTX28933	AKT (phospho Thr308) antibody	Rb pAb	Hu, Ms, Rat	ELISA, FACS, WB
GTX133175	AKT (phospho Thr450) antibody	Rb pAb	Hu, Ms, Rat	WB
GTX128414	AKT (phospho Ser473) antibody	Rb pAb	Hu, Ms, Rat	IHC-P, IP, WB
GTX132615	AKT (phospho Ser473) antibody	Rb pAb	Hu, Ms, Rat	WB
GTX28451	Angiopoietin 1 antibody	Rb pAb	Hu, Ms	ELISA, IHC-P, WB
GTX28452	Angiopoietin 2 antibody	Rb pAb	Hu, Ms	ELISA, IHC-P, WB
GTX100991	Angiopoietin 2 antibody	Rb pAb	Hu, Ms	ICC/IF, IHC-P, WB
GTX100928	Angiopoietin 2 antibody	Rb pAb	Hu, Ms	IHC-P, WB
GTX129407	AXL antibody	Rb pAb	Hu	ELISA, IHC-P, WB
GTX101345	AXL antibody [C2C3], C-term	Rb pAb	Hu	IHC-P, WB
GTX132386	AXL antibody	Rb pAb	Hu	WB
GTX632645	CD31 antibody [GT0010]	Ham mAb	Ms, Rat	FACS, IHC-P
GTX110602	CD31 antibody [N3C2], Internal	Rb pAb	Hu	IHC-P, WB
GTX130274	CD31 antibody	Rb pAb	Ms	IHC-P, WB
GTX20218	CD31 antibody [WM59]	Ms mAb	Hu, Ms, RMK, ClMK	FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, IHC-Wm
GTX100904	CDC42 antibody	Rb pAb	Ms, Rat	IHC-P, WB
GTX134588	CDC42 antibody	Rb pAb	Hu	WB
GTX100656	COX2 antibody [C3], C-term	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX129843	eNOS antibody	Rb pAb	Hu	ICC/IF, WB
GTX133404	eNOS antibody	Rb pAb	Hu	WB
GTX83305	eNOS antibody [6H2]	Ms mAb	Hu	ELISA, IHC-P
GTX129058	eNOS (phospho Ser1177) antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX100699	ERK1 antibody	Rb pAb	Hu	WB
GTX113094	ERK2 antibody [N2C3]	Rb pAb	Hu, Ms, Pig, Rat	IHC-P, IP, WB
GTX134462	ERK1/2 antibody	Rb pAb	Hu	WB
GTX82780	FAK antibody [10H7]	Ms mAb	Hu, Ms	ELISA, ICC/IF, IHC-P, WB
GTX129840	FAK (phospho Tyr397) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
GTX132320	FAK (phospho Tyr407) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, WB
GTX132140	FAK (phospho Tyr576) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, WB
GTX24804	FAK (phospho Tyr861) antibody	Rb pAb	Hu, Ms, Chk, Dog, Rat, Zfsh, Amph, Hm, Xenopus	ICC/IF, IHC, IHC-P, IP, WB
GTX81891	FGF1 antibody, N-term	Rb pAb	Hu	ICC/IF, IHC-P, WB
GTX84502	FGF2 antibody [3D9]	Ms mAb	Hu, Mk	ICC/IF, IHC-P, WB
GTX111253	GAB1 antibody	Rb pAb	Hu, Ms	IHC-P, WB
GTX114226	GAB2 antibody [N1C1]	Rb pAb	Hu	WB
GTX39987	Integrin alpha V + beta 5 antibody [P1F6]	Ms mAb	Hu, Chk	ELISA, FACS, ICC/IF, IHC-Fr, IP
GTX100789	Integrin alpha V antibody [C2C3], C-term	Rb pAb	Hu, Ms	ELISA, IHC-P, WB
GTX111672	Integrin beta 3 antibody [N2C1], Internal	Rb pAb	Hu	WB
GTX102680	Integrin beta 5 antibody [N1C1]	Rb pAb	Hu	WB
GTX104577	MMP2 antibody	Rb pAb	Hu, Ms	ICC/IF, IHC-P, IP, WB
GTX634832	MMP2 antibody [GT185]	Ms mAb	Hu	WB
GTX100723	MMP3 antibody [N3C1], Internal	Rb pAb	Hu	ICC/IF, IHC-P, WB
GTX103647	MMP3 antibody [N1C1]	Rb pAb	Hu, Bov	IHC-P, WB
GTX100458	MMP9 antibody [N2C1], Internal	Rb pAb	Hu, Bov	ICC/IF, IHC-P, WB
GTX127932	NFAT1 antibody	Rb pAb	Hu, Ms	ICC/IF, IP, WB
GTX22722	NFAT1 antibody [25A10.D6.D2]	Ms mAb	Hu, Ms, Rat	FACS, GSA, ICC/IF, IHC-Fr, IHC-P, IP, WB, ChIP assay
GTX25246	NFAT1 (phospho Ser54) antibody	Rb pAb	Hu, Ms	FACS, ICC/IF, WB
GTX28925	NOTCH1 antibody	Rb pAb	Hu, Ms, Rat	ELISA, ICC/IF, IHC-P, Neut, WB
GTX101593	NOTCH2 antibody [C2], C-term	Rb pAb	Hu, Ms	WB, ChIP-seq
GTX127947	Neuropilin 1 antibody	Rb pAb	Ms, Rat	IHC-P, WB
GTX102397	NRP2 antibody [N2N3]	Rb pAb	Hu	WB
GTX110720	p38 MAPK antibody [N1C3-2]	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
GTX133460	p38 MAPK (phospho Thr180/Tyr182) antibody	Rb pAb	Hu	WB
GTX125891	Paxillin antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, IP, WB
GTX633769	Paxillin antibody [GT7612]	Ms mAb	Hu	ICC/IF, WB
GTX132154	Paxillin (phospho Tyr31) antibody	Rb pAb	Hu	ICC/IF, WB
GTX132152	Paxillin (phospho Tyr118) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, WB
GTX633707	Paxillin (non-phospho Tyr118) antibody [GT722]	Ms mAb	Hu, Ms, Rat	ICC/IF, WB
GTX132362	Paxillin (phospho Ser273) antibody	Rb pAb	Hu, Ms	WB
GTX107903	PDGF Receptor alpha antibody [N2C2], Internal	Rb pAb	Hu, Ms, Rat	WB
GTX133588	PDGF Receptor alpha antibody	Rb pAb	Ms	WB
GTX133587	PDGF Receptor beta antibody	Rb pAb	Hu	WB
GTX100683	PDGF beta antibody	Rb pAb	Hu	IHC-P, WB
GTX54575	PDGF beta antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX100462	PI3 kinase p110 alpha antibody	Rb pAb	Hu, Ms	ICC/IF, IHC-P, WB
GTX111173	PI3 kinase p110 beta antibody [N3C2], Internal	Rb pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
GTX74710	PI3 kinase p85 beta antibody [T15]	Ms mAb	Hu, Mk, Bov	IHC-Fr, IP, WB
GTX50858	PI3 kinase p85 (phospho Tyr467)/p55 (phospho Tyr199) antibody	Rb pAb	Hu, Ms, Rat	WB
GTX108953	PI3 kinase p150 antibody [C1C3]	Rb pAb	Hu	IP, WB
GTX132466	PI3 kinase p150 antibody	Rb pAb	Hu, Ms	IHC-P, IP, WB
GTX133546	PLCG1 antibody	Rb pAb	Hu, Ms, Rat	WB
GTX133465	PLCG1 (phospho Tyr783) antibody	Rb pAb	Hu, Ms	WB
GTX133466	PLCG1 (phospho Ser1248) antibody	Rb pAb	Hu	WB
GTX32238	PLCG1 (phospho Tyr1253) antibody	Rb pAb	Hu, Ms, Rat	ICC/IF, WB
GTX111293	PLCG2 antibody [N1N2], N-term	Rb pAb	Hu, Ms	ICC/IF, IHC-P, WB
GTX133463	PLCG2 (phospho Tyr759) antibody	Rb pAb	Hu	WB
GTX133610	PLCG2 (phospho Tyr1217) antibody	Rb pAb	Hu, Ms	WB
GTX13048	RAC antibody [23A8]	Ms mAb	Hu, Ms, Rat	IHC-Fr, IP, WB
GTX130671	Semaphorin 3A antibody	Rb pAb	Hu, Ms, Rat	IHC-P, WB
GTX130023	TGF beta 1 antibody	Rb pAb	Hu, Ms	WB
GTX134209	TGF beta Receptor I antibody	Rb pAb	Hu	WB
GTX129909	TGF beta Receptor II antibody	Rb pAb	Hu	WB
GTX109068	TGF beta Receptor III antibody	Rb pAb	Hu	WB