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Cancer Immune Checkpoints

Cancer Immune Checkpoints

Cancer Immune Checkpoints

Increasing knowledge of how cancer cells escape immune destruction has significantly driven the evolution of cancer immunotherapy. In particular, studies describing how different immune checkpoints, including the PD-1 and CTLA-4 pathways, function to attenuate T cell antitumor activity have revealed novel opportunities for therapeutic intervention. Researchers have made promising strides in inhibiting these checkpoints to unleash the T cells’ tumor-killing potential. Given that both radiotherapy and chemotherapy can also mobilize antitumor T cells, there is great excitement that checkpoint inhibition and other immunomodulatory approaches can be combined with conventional modalities to maximize clinical outcomes for a number of malignancies.

GeneTex Proudly Provides an Outstanding PD-L1 Antibody for Your Research

       
    Used at 1:1000 for IHC
    Knockout/knockdown validation
    Highly specific and sensitive
    Citation support
PD-L1 antibody (GTX104763)
Citation Support   KOKD Validation Comparable Abs Orthogonal Validation Protein Overexpression

 

PD-L1 antibody

KO/KD-Validated

PD-L1 antibody

IHC

PD-L1 antibody

Target Specificity

 

Click here to view the full list of antibodies for the study of immune checkpoints

 

Highlighted Products
Citation Support   KOKD Validation Orthogonal Validation Protein Overexpression
PD-1 antibody
(GTX20256)

PD-1 antibody
(GTX20256)

CTLA4 antibody
(GTX57204)

CTLA4 antibody
(GTX57204)

CD4 antibody
(GTX44531)

CD4 antibody
(GTX44531)

CD86 antibody
(GTX41787)

CD86 antibody
(GTX41787)

4-1BB / CD137 antibody [17B5] (FITC) (GTX43758)

4-1BB / CD137 antibody [17B5] (FITC) (GTX43758)

B7-H3 / CD276 antibody [MIH42] (PE) (GTX43126)

B7-H3 / CD276 antibody [MIH42] (PE) (GTX43126)

TIM-3 antibody
(GTX54055)

TIM-3 antibody
(GTX54055)

LAG3 antibody [C9B7W] (Low endotoxin, azide free)
(GTX42244)

LAG3 antibody [C9B7W] (Low endotoxin, azide free)
(GTX42244)

IDO1 antibody [GT273]
(GTX634652)

IDO1 antibody [GT273]
(GTX634652)

 

Newsletter
Article Alert: ATR Inhibition Enhances anti-PD-L1-based Immunotherapy Through Different Mechanisms

Article Alert: ATR Inhibition Enhances anti-PD-L1-based Immunotherapy Through Different Mechanisms

Literature

Flyer - IVD-related Products

Download the latest version of GeneTex's IVD-related Products flyer.
Literature

Flyer - Cited Antibodies 2024 Q2

Download the latest version of GeneTex's Antibodies for Cited Antibodies 2024 Q2 flyer.
Newsletter
Article Alert: Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Ductal Adenocarcinoma

Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Cancer

Newsletter
Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Literature

Poster - The Tumor Microenvironment (TME) - Part 2

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 2 poster.
Literature

Poster - The Tumor Microenvironment (TME) - Part 1

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 1 poster.
Literature

Poster - Cancer-associated-cells

Download the latest version of GeneTex's cancer-associated-cells poster.
Literature

Poster - Pre-Metastatic Niche

Download the latest version of GeneTex's Pre-Metastatic Niche poster.
Articles

IVD-related Products and Services

Newsletter
Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Newsletter
Article Alert: IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

Newsletter
PARPs as Therapeutic Targets in Clinical Oncology

PARPs as Therapeutic Targets in Clinical Oncology

Newsletter
HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

Newsletter
Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Newsletter
ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease
Newsletter
Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic anhydrase IX (CA IX) is a transmembrane, hypoxia-induced zinc metalloenzyme that converts carbon dioxide to bicarbonate and protons...
Newsletter

A Rising StAR in Cancer Research

Steroidogenic acute regulatory protein 1 (StAR/StARD1) mediates the rate-limiting step in steroidogenesis...
Newsletter

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation
Newsletter
Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells
Newsletter

Lateral Flow Assay for Influenza & SARS-CoV-2 Viruses Detection

Influenza A & B Virus Antibodies (IVD grade)
Literature
Brochure - Cited Antibodies

Brochure - Cited Antibodies

Download the latest version of GeneTex's Cited Antibodies brochure.
Newsletter
New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2
Literature

Flyer-Cancer

Download the latest version of GeneTex's Cancer flyer.
Literature
Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpoint flyer
Newsletter
GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex's RAS (G12D mutant) recombinant antibody is suitable for IHC staining and WB.
Literature
Download the latest version of GeneTex's Zika Virus Research flyer.

Flyer-Zika Virus Research

Download the latest version of GeneTex's Zika Virus Research flyer.
Literature

Flyer - IVD-related Products

Download the latest version of GeneTex's IVD-related Products flyer.
Literature

Flyer - Cited Antibodies 2024 Q2

Download the latest version of GeneTex's Antibodies for Cited Antibodies 2024 Q2 flyer.
Literature

Poster - The Tumor Microenvironment (TME) - Part 2

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 2 poster.
Literature

Poster - The Tumor Microenvironment (TME) - Part 1

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 1 poster.
Literature

Poster - Cancer-associated-cells

Download the latest version of GeneTex's cancer-associated-cells poster.
Literature

Poster - Pre-Metastatic Niche

Download the latest version of GeneTex's Pre-Metastatic Niche poster.
Literature
Brochure - Cited Antibodies

Brochure - Cited Antibodies

Download the latest version of GeneTex's Cited Antibodies brochure.
Literature

Flyer-Cancer

Download the latest version of GeneTex's Cancer flyer.
Literature
Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

Download the latest version of GeneTex's cancer immune checkpoint flyer
Literature
Download the latest version of GeneTex's Zika Virus Research flyer.

Flyer-Zika Virus Research

Download the latest version of GeneTex's Zika Virus Research flyer.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Metabolic Pathways

Flyer - Metabolic Pathways

Download the latest version of GeneTex's metabolic pathways flyer.
Literature

Flyer - RNA-binding Proteins

Download the latest version of GeneTex's RNA-binding proteins flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Newsletter
Article Alert: ATR Inhibition Enhances anti-PD-L1-based Immunotherapy Through Different Mechanisms

Article Alert: ATR Inhibition Enhances anti-PD-L1-based Immunotherapy Through Different Mechanisms

Newsletter
Article Alert: Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Ductal Adenocarcinoma

Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Cancer

Newsletter
Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Newsletter
Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Newsletter
Article Alert: IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

Newsletter
PARPs as Therapeutic Targets in Clinical Oncology

PARPs as Therapeutic Targets in Clinical Oncology

Newsletter
HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

Newsletter
Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Newsletter
ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease
Newsletter
Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic anhydrase IX (CA IX) is a transmembrane, hypoxia-induced zinc metalloenzyme that converts carbon dioxide to bicarbonate and protons...
Newsletter

A Rising StAR in Cancer Research

Steroidogenic acute regulatory protein 1 (StAR/StARD1) mediates the rate-limiting step in steroidogenesis...
Newsletter

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation
Newsletter
Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells
Newsletter

Lateral Flow Assay for Influenza & SARS-CoV-2 Viruses Detection

Influenza A & B Virus Antibodies (IVD grade)
Newsletter
New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2
Newsletter
GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex's RAS (G12D mutant) recombinant antibody is suitable for IHC staining and WB.
Newsletter
Cancer Immunotherapy

A Cancer Immunotherapy Holy Grail?

A Cancer Immunotherapy Holy Grail?
Newsletter
exosome PD-L1

Improving cancer immunotherapy efficacy may depend on targeting exosomes

Improving cancer immunotherapy efficacy may depend on targeting exosomes bearing the immune checkpoint protein PD-L1