GeneTex
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DNA Methylation

The mammalian TET proteins (Ten Eleven Translocation) encode 5-methylcytosine (5-mC) dioxygenases. There are three TETs in human: TET1, TET2, and TET3. These TET proteins convert 5-mC to 5-hydroxymethylcytosine (5-hmC) and subsequently to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). This series of modifications is thought to represent one pathway to active DNA demethylation, thereby reshaping the methylated DNA landscape established by DNA methyltransferases (DNMTs). In addition, these marks, particularly 5-hmC, have been shown to be distinct epigenetic signatures in their own right impacting stem cell and cancer cell biology. TET proteins have also been shown to be components of crosstalk mechanisms between DNA and histone modifications that determine gene expression status. Thus, within the span of a few years, the TET proteins have become recognized as central players in gene regulation, pluripotency, cell differentiation, and carcinogenesis. It is clear that researchers have crossed a threshold into an exciting new realm of epigenetics research, with countless discoveries waiting to be made. GeneTex is proud to introduce a selection of its antibodies to targets relevant to DNA methylation and demethylation, histone modification, and cell pluripotency. Many of the antibodies are suitable for IP/ChIP applications.

Highlighted Products

      
Cat. No. Product Name Items Host & Clonality Applications  
GTX300098 TET Family TET1 antibody [N3C1] Rb pAb ICC/IF, IHC, IHC-P, IP, WB, ChIP assay   
TET2 antibody [N2-2], N-term Rb pAb ICC/IF, IHC-P, IP, WB, ChIP assay   
TET3 antibody [C3], C-term Rb pAb ICC/IF, IHC-P, IP, WB, IHC-Wm, ChIP assay  
Goat anti-Rabbit IgG (HRP) Gt pAb Dot, ELISA, ICC/IF, IHC-P, WB
GTX300099 TET family, 5-mC and 5-hmC TET1 antibody [N3C1] Rb pAb ICC/IF, IHC, IHC-P, IP, WB, ChIP assay   
TET2 antibody [N2-2], N-term Rb pAb ICC/IF, IHC-P, IP, WB, ChIP assay   
TET3 antibody [C3], C-term Rb pAb ICC/IF, IHC-P, IP, WB, IHC-Wm, ChIP assay  
5-Methylcytosine / 5-mC antibody [GT4111] Hu, Ms, Rat Dot, EM, IHC-P, IHC-Wm, MeDIP  

 

TET Antibodies

TET1 antibody (GTX627420)

      

TET2 antibody [N2-2], N-term (GTX124205)

   

TET3 antibody [C3], C-term (GTX121453)

 
 
 

DNMT Antibodies

DNMT1 antibody [N1], N-term (GTX116011)

 

DNMT3A antibody (GTX129125)

 

DNMT3B antibody (GTX129127)

   
 
 

5-mC, 5-hmC and 5-caC Antibodies

5-Methylcytosine / 5-mC antibody [GT4111] (GTX629448)

 

5-Methylcytosine/ 5-mC antibody (GTX128455)

5-HydroxymethylCytidine antibody [GT13612] (GTX629765)

 

 TET Antibodies

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX627420 TET1 antibody [GT1462] Ms mAb Hu, Ms ICC/IF, IHC-P, IP, WB, ChIP assay   
GTX124207 TET1 antibody [N3C1] Rb pAb Hu, Ms, Mk ICC/IF, IHC, IHC-P, IP, WB, ChIP assay   
GTX125888 TET1 antibody [N1], N-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB, ChIP assay  
GTX629974 TET1 antibody [GT465] Ms mAb Hu ICC/IF, WB
GTX124205 TET2 antibody [N2-2], N-term Rb pAb Hu ICC/IF, IHC-P, IP, WB, ChIP assay   
GTX124204 TET2 antibody [N2], N-term Rb pAb Hu ICC/IF, IP, WB, ChIP assay
GTX629879 TET2 antibody [GT411] Ms mAb Hu IP, WB
GTX629881 TET2 antibody [GT649] Ms mAb Hu IP, WB, ChIP assay
GTX131099 TET2 antibody Ms pAb Hu WB, ChIP assay  
GTX121453 TET3 antibody [C3], C-term Rb pAb Hu, Ms, Xl, Bov ICC/IF, IHC-P, IP, WB, IHC-Wm, ChIP assay  
GTX121452 TET3 antibody [N3C1], Internal Rb pAb Hu WB
GTX628257 TET3 antibody [GT334] Ms mAb Hu WB  
GTX628893 TET3 antibody [GT859] Ms mAb Hu WB  

 

DNMT Antibodies

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX116011 DNMT1 antibody [N1], N-term Rb pAb Hu ICC/IF, IHC-P, IP, WB, ChIP assay
GTX30364 DNMT1 antibody Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB  
GTX13892 DNMT2 antibody Rb pAb Hu, Ms WB
GTX129125 DNMT3A antibody Rb pAb Hu, Ms, Rat EM, ICC/IF, IHC-P, IP, WB  
GTX129126 DNMT3A antibody Rb pAb Hu, Ms, Rat IP, WB  
GTX128157 DNMT3A antibody Rb pAb Hu WB
GTX30365 DNMT3A antibody Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
GTX129127 DNMT3B antibody Rb pAb Hu, Rat ICC/IF, IHC-P, IP, WB    
GTX125917 DNMT3B antibody Rb pAb Hu WB  
GTX115985 DNMT3L antibody [N1C1] Rb pAb Hu ICC/IF, WB  

 

 5-mC, 5-hmC and 5-caC Antibodies

Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX128455 5-Methylcytosine / 5-mC antibody Rb pAb Other Dot, EM, MeDIP
GTX629448 5-Methylcytosine / 5-mC antibody [GT4111] Ms mAb Other Dot, EM, IHC-P, IHC-Wm, MeDIP
GTX21884 5-Methylcytosine / 5-mC antibody Shp pAb Other Dot, FACS, ICC/IF, IHC, IHC-Fr, IP, WB
GTX75897 5-Methylcytosine / 5-mC antibody [33D3] Ms mAb Other ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IB, MeDIP
GTX629765 5-Hydroxymethylcytosine / 5-hmC antibody [GT13612] Ms mAb Other Dot, EM, IHC-Fr, IHC-P, MeDIP
GTX629701 5-Hydroxymethylcytosine / 5-hmC antibody [GT513] Ms mAb Other Dot, MeDIP  
GTX128454 5-Hydroxymethylcytosine / 5-hmC antibody Rb pAb Other Dot, MeDIP  
GTX60801 5-Carboxylcytosine / 5-caC antibody Rb pAb Other Dot, ICC/IF, IP  

 

 

Literature
Flyer - Epigenetics DNA Methylation

Flyer - Epigenetics DNA Methylation

Download the latest version of GeneTex's epigenetics DNA methylation flyer.
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Flyer - Epigenetics DNA Methylation

Flyer - Epigenetics DNA Methylation

Download the latest version of GeneTex's epigenetics DNA methylation flyer.
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.