2019 Novel Coronavirus (SARS-CoV-2) is a positive-sense, single-stranded RNA virus that can cause COVID-19 disease, a lethal respiratory disease. This new virus belongs to the genus Betacoronavirus, which also includes SARS-CoV and MERS-CoV. The first case of COVID-19 was detected in December, 2019 in Wuhan, China, and subsequently spread to other countries in Asia, North America, Europe, and Oceania (1). Human-to-human spread has been confirmed, with a suspected incubation period of ~2-14 days. There are some reports of transmission in the absence of clear symptoms, though infected people are likely most contagious due to coughing and sneezing that expel respiratory droplets. Angiotensin-converting enzyme 2 (ACE2), the host receptor for SARS-CoV and HCoV-NL63, is also the main entry gate for 2019-nCoV via its spike protein (2, 3).
For more information and the latest updates regarding COVID-19, please visit the CDC’s website.
ACE2 antibody [N1N2] (GTX101395)