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Summary This MAb reacts with a 200kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase, this Ab no longer binds.

Summary Screening was performed by ELISA using the immunogen, followed by immunofluorescence microscopy. Clones which revealed strong staining were further characterized biochemically.