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CD45RA antibody [MSVA-472M] HistoMAX™ Cat No. GTX04372

HistoMAX

Summary Highly recommended for IHC-P in human tissues.

Myeloperoxidase antibody [MSVA-692M] HistoMAX™ Cat No. GTX04470

HistoMAX

Summary Highly recommended for IHC-P in human tissues.

Iba1 antibody [MSVA-955M] HistoMAX™ Cat No. GTX04465

HistoMAX

Summary Highly recommended for IHC-P in human tissues.

Summary The complete 145-2C11 antibody is commonly used to stimulate T cells in vitro however, when used in vivo activation of resting T cells results in cytokine release and toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor-bearing cells. To avoid these complications non-Fc receptor binding F(ab’)2 fragments of the 145-2C11 antibody are commonly used. This non-FcR-binding anti-CD3 induces apoptosis of Ag-activated T cells in vivo  by allowing durable expression of the TCR and sustained signaling. Foxp3+ Tregs have been shown to be resistant to CD3 antibody-mediated depletion.