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Summary The complete 145-2C11 antibody is commonly used to stimulate T cells in vitro however, when used in vivo activation of resting T cells results in cytokine release and toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor-bearing cells. To avoid these complications non-Fc receptor binding F(ab’)2 fragments of the 145-2C11 antibody are commonly used. This non-FcR-binding anti-CD3 induces apoptosis of Ag-activated T cells in vivo  by allowing durable expression of the TCR and sustained signaling. Foxp3+ Tregs have been shown to be resistant to CD3 antibody-mediated depletion.

GBP5 antibody Cat No. GTX31537

1 References

Orthogonal

Summary GBP5 antibody is predicted to not cross-react with other GBP family members.

DDX60 antibody Cat No. GTX32082

3 References

KO/KD

Summary At least three isoforms of DDX60 are known to exist; this antibody will detect all three isoforms.