14-3-3

CCDC14 antibody [C2C3], C-term GTX120754

References 3

KO/KD

Summary KO/KD validation is based on published data (PMID: 26297806).

CD146 antibody [N1N3] GTX102413

KO/KD

Summary This antibody was raised against human CD146 Extracellular domain.

RFP antibody [GT1433] GTX628898

References 1

Carrier-Free

Summary This antibody is specific for RFP and does not cross react with GFP.

Summary The complete 145-2C11 antibody is commonly used to stimulate T cells in vitro however, when used in vivo activation of resting T cells results in cytokine release and toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor-bearing cells. To avoid these complications non-Fc receptor binding F(ab’)2 fragments of the 145-2C11 antibody are commonly used. This non-FcR-binding anti-CD3 induces apoptosis of Ag-activated T cells in vivo  by allowing durable expression of the TCR and sustained signaling. Foxp3+ Tregs have been shown to be resistant to CD3 antibody-mediated depletion.

CD147 antibody [N2C3] GTX100915

Orthogonal

Summary This antibody was raised against human CD147 Extracellular domain.