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Epithelial-Mesenchymal Transition

Epithelial-Mesenchymal Transition

Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) is a process whereby largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways (e.g., TGF-beta, Wnt/beta-catenin, integrins, and Notch) have been reported to induce EMT via cytoskeleton rearrangement and activation of E-cadherin repressors, including Snail, Slug, SIP1, ZEB1, and TCF3.

 
 

 

EMT-inducing Transcription Factors

beta Catenin antibody

beta Catenin antibody
(GTX101435)

Citation Support KOKD Validation
SNAI1 antibody

SNAI1 antibody
(GTX100754)

Citation Support IP/MS Orthogonal Validation
Twist1/2 antibody

Twist1/2 antibody
(GTX127310)

Citation Support Protein Overexpression
 

 

Epithelial Markers

E-Cadherin antibody

E-Cadherin antibody
(GTX100443)

Citation Support KOKD Validation Orthogonal Validation
Cytokeratin 8 antibody

Cytokeratin 8 antibody
(GTX112975)

Citation Support KOKD Validation
Cytokeratin 18 antibody

Cytokeratin 18 antibody
(GTX112978)

Citation Support KOKD Validation
 

 

Mesenchymal Markers

alpha Smooth Muscle Actin antibody

alpha Smooth Muscle Actin antibody
(GTX100034)

Citation Support KOKD Validation
Fibronectin antibody

Fibronectin antibody
(GTX112794)

Citation Support KOKD Validation Orthogonal Validation
N-Cadherin antibody

N-Cadherin antibody
(GTX127345)

Citation Support KOKD Validation
 

 

Pathways

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Pathways

Epithelial–mesenchymal transition (EMT) Pathway

EMT is a process whereby tightly-interacting and immotile epithelial cells acquire the phenotype of loosely-adherent and motile mesenchymal cells.
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Flyer - Epithelial–Mesenchymal Transition

Download the latest version of GeneTex's epithelial–mesenchymal transition flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Poster - EMT

Download the latest version of GeneTex's EMT poster
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Flyer - Epithelial–Mesenchymal Transition

Download the latest version of GeneTex's epithelial–mesenchymal transition flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Poster - EMT

Download the latest version of GeneTex's EMT poster