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Epithelial-Mesenchymal Transition

Epithelial-Mesenchymal Transition

Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) is a process whereby largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways (e.g., TGF-beta, Wnt/beta-catenin, integrins, and Notch) have been reported to induce EMT via cytoskeleton rearrangement and activation of E-cadherin repressors, including Snail, Slug, SIP1, ZEB1, and TCF3.

 

EMT-inducing Transcription Factors

 
   
beta Catenin antibody

beta Catenin antibody
(GTX101435)
Citation SupportKOKD Validation
SNAI1 antibody

SNAI1 antibody
(GTX100754)
Citation SupportOrthogonal Validation
Twist1/2 antibody

Twist1/2 antibody
(GTX127310)
Citation SupportOrthogonal ValidationProtein Overexpression
 

 

Epithelial Markers

 
    
E-Cadherin antibody

E-Cadherin antibody
(GTX100443)
Citation SupportKOKD ValidationOrthogonal Validation
Cytokeratin 8 antibody

Cytokeratin 8 antibody
(GTX112975)
Citation SupportKOKD Validation
Cytokeratin 18 antibody

Cytokeratin 18 antibody
(GTX112978)
Citation SupportKOKD Validation
 

 

Mesenchymal Markers

 
   
alpha Smooth Muscle Actin antibody

alpha Smooth Muscle Actin antibody
(GTX100034)
Citation SupportKOKD ValidationOrthogonal Validation
Fibronectin antibody

Fibronectin antibody
(GTX112794)
Citation SupportKOKD ValidationOrthogonal Validation
N-Cadherin antibody

N-Cadherin antibody
(GTX127345)
Citation SupportKOKD ValidationOrthogonal Validation
 

 

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Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 2 poster.
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Poster - The Tumor Microenvironment (TME) - Part 1

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Poster - Cancer-associated-cells

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Poster - Pre-Metastatic Niche

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IVD-related Products and Services

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Download the latest version of GeneTex's Cited Antibodies brochure.
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GeneTex's RAS (G12D mutant) recombinant antibody is suitable for IHC staining and WB.
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Flyer - IVD-related Products

Download the latest version of GeneTex's IVD-related Products flyer.
Literature

Flyer - Cited Antibodies 2024 Q2

Download the latest version of GeneTex's Antibodies for Cited Antibodies 2024 Q2 flyer.
Literature

Poster - The Tumor Microenvironment (TME) - Part 2

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 2 poster.
Literature

Poster - The Tumor Microenvironment (TME) - Part 1

Download the latest version of GeneTex's The Tumor Microenvironment (TME) - Part 1 poster.
Literature

Poster - Cancer-associated-cells

Download the latest version of GeneTex's cancer-associated-cells poster.
Literature

Poster - Pre-Metastatic Niche

Download the latest version of GeneTex's Pre-Metastatic Niche poster.
Literature
Brochure - Cited Antibodies

Brochure - Cited Antibodies

Download the latest version of GeneTex's Cited Antibodies brochure.
Literature

Flyer-Cancer

Download the latest version of GeneTex's Cancer flyer.
Literature
Cancer Immune Checkpoints

Flyer - Cancer Immune Checkpoints

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Download the latest version of GeneTex's Zika Virus Research flyer.

Flyer-Zika Virus Research

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Cited Antibodies

Flyer - Cited Antibodies

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World Class Validated Antibodies

Brochure - World Class Validated Antibodies

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Cancer Signaling

Poster - Cancer Signaling

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Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

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Flyer - Epithelial–Mesenchymal Transition

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Flyer - Metabolic Pathways

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Flyer - RNA-binding Proteins

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Pamphlet - Hot Products

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Epithelial–Mesenchymal Transition

Poster - EMT

Download the latest version of GeneTex's EMT poster
Newsletter
Article Alert: Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Ductal Adenocarcinoma

Acquired Resistance to Immunotherapy is Mediated by EMT and Irf6 Repression in Pancreatic Cancer

Newsletter
Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Article Alert: Stromal Monoamine Oxidase B Drives Prostate Cancer

Newsletter
Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Article Alert: Tumor-associated neutrophils require CD300ld to promote cancer progression

Newsletter
Article Alert: IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

IFNγ-stimulated KAT8-IRF1 Condensates Activate PD-L1 Expression and Promote Immune Evasion

Newsletter
Article Alert: Targeting the MMP-2/TYRO3/BRD3 Axis Ameliorates Colorectal Cancer Malignancy

Article Alert: Targeting the MMP-2/TYRO3/BRD3 Axis Ameliorates Colorectal Cancer Malignancy

Newsletter
PARPs as Therapeutic Targets in Clinical Oncology

PARPs as Therapeutic Targets in Clinical Oncology

Newsletter
HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

HCK Inhibition: Boosting Immunotherapy’s Efficacy and Utility?

Newsletter
Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Article Alert: C3aR and TNF-αR Antagonists as Potential Therapies for Medulloblastoma

Newsletter
Novel Antibodies for E-cadherin Research

Novel Antibodies for E-cadherin Research

E-cadherin (epithelial-cadherin), like placental-cadherin (P-cadherin) and neural-cadherin (N-cadherin)...
Newsletter
ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease

ADAM17: A Major “Sheddase” in Human Disease
Newsletter
Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic anhydrase IX (CA IX) is a transmembrane, hypoxia-induced zinc metalloenzyme that converts carbon dioxide to bicarbonate and protons...
Newsletter

A Rising StAR in Cancer Research

Steroidogenic acute regulatory protein 1 (StAR/StARD1) mediates the rate-limiting step in steroidogenesis...
Newsletter

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation
Newsletter
Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells

Nuclear PD-L1 Mediates Pyroptosis in Cancer Cells
Newsletter

Lateral Flow Assay for Influenza & SARS-CoV-2 Viruses Detection

Influenza A & B Virus Antibodies (IVD grade)
Newsletter
New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2

New Therapeutic Paradigm for Cancers with Activated NRF2
Newsletter
GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex's RAS (G12D mutant) recombinant antibody is suitable for IHC staining and WB.
Newsletter
Cancer Immunotherapy

A Cancer Immunotherapy Holy Grail?

A Cancer Immunotherapy Holy Grail?