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Oncoproteins

Oncoproteins

Oncoproteins

The products of metazoan cell proto-oncogenes are generally key constituents of the cell signaling and gene expression machinery that regulate cell growth and proliferation. When mutated, amplified, or otherwise expressed in a dysregulated manner, these genes can become cellular oncogenes and their oncoprotein products drive tumorigenic cell growth. Examples of proto-oncogenes include the RAS genes, ERBB2, MYC, and ABL1. Certain viruses, or oncoviruses, have the capability to cause cancers through the action of viral genome-encoded oncoproteins that target metazoan cell factors or pathways.
Highlighted Products
 

 

Oncoproteins: Cell Signaling

AKT antibody [N3C2], Internal

AKT antibody [N3C2], Internal
(GTX121937)
Ras antibody

Ras antibody
(GTX132480)
Aurora B antibody

Aurora B antibody
(GTX130211)
 

 

Oncoproteins: Growth Factors and Receptors

VEGF antibody

VEGF antibody
(GTX102643)
EGFR antibody [N1-2], N-term

EGFR antibody [N1-2], N-term
(GTX121919)
Phospho-EGF Receptor (Tyr1068) antibody

Phospho-EGF Receptor (Tyr1068) antibody
(GTX132810)
 
Her2 / ErbB2 antibody [C2C3], C-term

Her2 / ErbB2 antibody [C2C3], C-term
(GTX100509)
Her2 / ErbB2 (phospho Tyr1221/Tyr1222) antibody

Her2 / ErbB2 (phospho Tyr1221/Tyr1222) antibody
(GTX133445)
PDGF Receptor beta (phospho Tyr751) antibody

PDGF Receptor beta (phospho Tyr751) antibody
(GTX133525)
 

 

Oncoproteins: Transcription Factors

c-Fos antibody

c-Fos antibody
(GTX129846)
c-Jun antibody

c-Jun antibody
(GTX134395)
c-Myc antibody

c-Myc antibody
(GTX103436)
 

 

Oncoproteins: Virus-encoded Proteins

Human Papilloma virus type 16 E6 antibody

Human Papilloma virus type 16 E6 antibody
(GTX132686)
 
Human Papilloma virus type 18 E7 antibody [GT881]

Human Papilloma virus type 18 E7 antibody [GT881]
(GTX634337)
 
SV40 Large T antibody

SV40 Large T antibody
(GTX134377)
 

 

Pathways

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Flyer - EGFR Signaling

Download the latest version of GeneTex's EGFR signaling flyer.
Literature

Pamphlet - Hot Products

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Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Flyer - EGFR Signaling

Download the latest version of GeneTex's EGFR signaling flyer.
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research