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PCAF antibody Cat No. GTX12188

Orthogonal

Summary PCAF (p300/CBP associated factor, P/CAF), a type A histone acetyltransferases (HAT), has been identified in several species. Human PCAF is a ubiquitous protein member of the GCN5-related N-acetyltransferase (GNAT) superfamily. It interacts with the p300 and CBP (CREB-binding protein) transcriptional coactivators and may be found in multi-subunit protein complexes formed from more than 20 polypeptides ranging from 10 to 400 kDa.PCAF shows extensive sequence similarity to human and mouse GCN5 HAT. Human PCAF acetylates all four core-histones. It also acetylates nonhistone proteins such as p53, MyoD, TFIIE-β, TFIIE, GATA-1, EKLF, HMGI (Y), and several other cellular and viral proteins. PCAF contributes to transcriptional activation by modifying chromatin and transcriptional factors. It is required in many cell growth and development processes such as myogenesis, and in nuclear receptor mediated or growth factor-signaled cell activation.