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Neurodegenerative Disorders

Neurodegenerative Disorders

Neurodegenerative Disorders
Despite a diverse array of clinical manifestations and affected genes, many of the common neurodegenerative disorders share a similar molecular mechanism. Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion disease are each characterized by the aggregation of mutated or misfolded proteins into amyloid inclusion bodies. Aggregation results when the accumulation of misfolded proteins exceeds the cell's ability to eliminate them via the ubiquitin-proteasome degradation pathway. Some evidence suggests that these inclusions may represent a cellular defense mechanism intended to sequester toxic oligomers or to induce autophagic elimination of the diseased proteins. Effective future strategies for treatment of these neurodegenerative disorders rely on the understanding of the basic pathways affected in these disorders.
 
Disease Type of Aggregation Subcellular Affected Protein Brain Region Affected
Alzheimer's Disease (AD) Neuritic Plaques Extracellular Amyloid beta peptide Cortex, hippocampus, basal forebrain, brain stem
Neurofibrillary tangles Intracellular Hyperphosphorylated Tau
Parkinson's Disease (PD) Lewy Body Intracellular (Cytoplasm) α-Synuclein Substantia nigra, cortex, locus ceruleus, rephe (dopaminergic neurons)
Huntington's Disease (HD) Intranuclear inclusions & cytoplasmic aggregates Intracellular Huntingtin with polyglutamate expansion Striatum, basal ganglia, cortex, others
Amyotrophic Lateral Sclerosis (ALS) Bonina bodies and axonal spheroids Intracellular (Cytoplasm) Various ALS genes Spinal motor neurons and motor cortex
Prion Disease Amyloid Plaque Intracellular & Extracellular Prion protein Cortex, brain stem, thalamus, cerebellum, other
 
GeneTex proudly offers an excellent catalog of high-quality antibodies to study the processes involved in neurodegenerative disorders, the majority of which are validated for multiple applications. Please view the table below of selected antibodies and consider whether they can help accelerate your research.
 
Alzheimer's Disease
 
APP antibody

beta amyloid (1-42) antibody-Conformation Specific (GTX134510)
Tau antibody

APP antibody
(GTX101336)
 
Apolipoprotein E antibody

Apolipoprotein E antibody (GTX101456)
 
 
Parkinson's Disease (PD)
 
alpha Synuclein antibody

alpha Synuclein antibody (GTX112799)
PGP9.5 antibody (GTX109637)

PGP9.5 antibody (GTX109637)
 
LRRK2 antibody (GTX113065)

LRRK2 antibody (GTX113065)
 
 
Huntington’s Disease (HD)
 
Huntingtin antibody (GTX132433)

Huntingtin antibody (GTX132433)
HIP1 antibody (GTX131449)

HIP1 antibody
(GTX131449)
 
HIP1 antibody

BDNF antibody
(GTX132621)
 
 
Amyotrophic Lateral Sclerosis (ALS)
  
C9orf72 antibody (GTX632041)

C9orf72 antibody
(GTX632041)
SOD1 antibody (GTX100554)

SOD1 antibody
(GTX100554)
TDP43 antibody (GTX630196)

TDP43 antibody
(GTX630196)
 
Prion Disease
 
Prion Protein/PRP antibody (GTX101063)

Prion Protein/PRP antibody (GTX101063)
 
Grp58/ERp57 antibody (GTX113719)

Grp58/ERp57 antibody
(GTX113719)
  
Grp78 antibody (GTX113340)

Grp78 antibody
(GTX113340)
 
 

 

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Flyer - Neurodegenerative Disorders

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Pamphlet - Hot Products

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