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Neurodegenerative Disorders

Neurodegenerative Disorders

Neurodegenerative Disorders
Despite a diverse array of clinical manifestations and affected genes, many of the common neurodegenerative disorders share a similar molecular mechanism. Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion disease are each characterized by the aggregation of mutated or misfolded proteins into amyloid inclusion bodies. Aggregation results when the accumulation of misfolded proteins exceeds the cell's ability to eliminate them via the ubiquitin-proteasome degradation pathway. Some evidence suggests that these inclusions may represent a cellular defense mechanism intended to sequester toxic oligomers or to induce autophagic elimination of the diseased proteins. Effective future strategies for treatment of these neurodegenerative disorders rely on the understanding of the basic pathways affected in these disorders.
 
Disease Type of Aggregation Cellular Localization Factor Involved Brain Region Affected
Alzheimer's Disease (AD) Neuritic Plaques Extracellular Amyloid beta peptide Cortex, hippocampus, basal forebrain, brain stem
Neurofibrillary tangles Intracellular Hyperphosphorylated Tau
Parkinson's Disease (PD) Lewy Body Intracellular (Cytoplasm) α-Synuclein Substantia nigra, cortex, locus ceruleus, rephe (dopaminergic neurons)
Huntington's Disease (HD) Intranuclear inclusions & cytoplasmic aggregates Intracellular Huntingtin with polyglutamate expansion Striatum, basal ganglia, cortex, others
Amyotrophic Lateral Sclerosis (ALS) Bonina bodies and axonal spheroids Intracellular (Cytoplasm) Various ALS genes Spinal motor neurons and motor cortex
Prion Disease Amyloid Plaque Intracellular & Extracellular Prion protein Cortex, brain stem, thalamus, cerebellum, other
 
GeneTex proudly offers an excellent catalog of high-quality antibodies to study the processes involved in neurodegenerative disorders, the majority of which are validated for multiple applications. Please view the table below of selected antibodies and consider whether they can help accelerate your research.
 
Alzheimer's Disease
  
APP antibody

beta amyloid (1-42) antibody-Conformation Specific (GTX134510)
Tau antibody

APP antibody
(GTX101336)
 
Apolipoprotein E antibody

Apolipoprotein E antibody (GTX101456)
 
 
Parkinson's Disease (PD)
   
alpha Synuclein antibody

alpha Synuclein antibody (GTX112799)
PGP9.5 antibody (GTX109637)

PGP9.5 antibody (GTX109637)
LRRK2 antibody (GTX113065)

LRRK2 antibody (GTX113065)
 
 
Huntington’s Disease (HD)
  
Huntingtin antibody (GTX132433)

Huntingtin antibody (GTX132433)
HIP1 antibody (GTX131449)

HIP1 antibody
(GTX131449)
 
HIP1 antibody

BDNF antibody
(GTX132621)
 
 
Amyotrophic Lateral Sclerosis (ALS)
   
C9orf72 antibody (GTX632041)

C9orf72 antibody
(GTX632041)
SOD1 antibody (GTX100554)

SOD1 antibody
(GTX100554)
TDP43 antibody

TDP43 antibody
(GTX114210)
 
Prion Disease
    
Prion Protein/PRP antibody (GTX101063)

Prion Protein/PRP antibody (GTX101063)
 
Grp58/ERp57 antibody (GTX113719)

Grp58/ERp57 antibody
(GTX113719)
 
Grp78 antibody (GTX113340)

Grp78 antibody
(GTX113340)
 

 

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For a limited time, get well-validated GeneTex antibodies at a great value!
Newsletter
GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

GeneTex's Iba1 recombinant antibody is suitable for IHC staining and WB.
Literature
Cited Antibodies

Flyer - Cited Antibodies

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Newsletter
Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies for the research of Amyotrophic lateral sclerosis.
Newsletter
Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

ApoE was identified as a major checkpoint inhibitor of the classical complement cascade, and involved in a possible unifying mechanism underlying Alzheimer’s disease, atherosclerosis, and potentially other inflammatory diseases.
Literature
Neurotransmission

Flyer - Neurotransmission

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Newsletter

Neurodegeneration: A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death

A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death
Newsletter

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.

A recent study by Ewers et al. reported that increased soluble TREM2 measured in cerebrospinal fluid was associated with lower rates of cognitive and clinical decline and progression in people with AD.
Newsletter

Clinical trials targeting alpha-synuclein protein in Parkinson’s disease

α-synuclein has become a major therapeutic target in PD. Multiple clinical trials are ongoing.
Literature
Recombinant Active Proteins

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Literature
World Class Validated Antibodies

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Literature
Neuroinflammation

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Articles
beta Amyloid

beta Amyloid

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific” can specifically detect amyloid plaques in the Alzheimer's Disease brain by IHC-P analysis. The superior specificity and sensitivity of this antibody were confirmed by dot blot, ELISA and side-by-side IHC-P comparison with competitor's.
Literature
Neuroscience Research

Pamphlet - Neuroscience Research

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Literature

Flyer - Amyotrophic Lateral Sclerosis

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Literature
Neurodegenerative Disorders

Poster - Neurodegenerative Disorders

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Literature
Neurodegenerative Disorders

Flyer - Neurodegenerative Disorders

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Literature

Pamphlet - Hot Products

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Literature
Cited Antibodies

Flyer - Cited Antibodies

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Literature
Neurotransmission

Flyer - Neurotransmission

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Literature
Recombinant Active Proteins

Pamphlet - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins Pamphlet.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

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Literature
Neuroinflammation

Flyer - Neuroinflammation

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Literature
Neuroscience Research

Pamphlet - Neuroscience Research

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Literature

Flyer - Amyotrophic Lateral Sclerosis

Download the latest version of GeneTex's amyotrophic lateral sclerosis flyer.
Literature
Neurodegenerative Disorders

Poster - Neurodegenerative Disorders

Download the latest version of GeneTex's neurodegenerative disorders poster.
Literature
Neurodegenerative Disorders

Flyer - Neurodegenerative Disorders

Download the latest version of GeneTex's neurodegenerative disorders flyer.
Literature

Pamphlet - Hot Products

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