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GeneTex Webinar Series

23-Aug-2021
Genetic and Metabolic Determinants of Tumor Evolution and Metastasis

新型コロナウイルスの進化 ~これまでとこれから~

2019年末に突如出現した新型コロナウイルスは、瞬く間に全世界に広がった。これまで、全世界において2億人以上が新型コロナウイルスに感染し、450万人以上が新型コロナウイルス感染症COVID-19によって死亡している。未曾有の新型コロナウイルスパンデミックは、発生から約2年あまりが経過した現在においても、リアルタイムの災禍であり、いまだ収束の兆しは見えない。
演者は、新型コロナウイルスの発生当初からこれまで、そのウイルス学的な性状の理解に向けたシステムウイルス学研究を展開してきた。本講演では、新型コロナウイルスについて、これまでの研究からわかってきたことを概説するとともに、これからの研究と流行の展望について広く議論したい。

When: 2021年11月5日(金), 11:00 a.m.

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Genetic and Metabolic Determinants of Tumor Evolution and Metastasis

Genetic and Metabolic Determinants of Tumor Evolution and Metastasis

Dr. Ngo’s research examines the complex interplay between genomic instability, nutrient constraints, and metabolic synthetic processes that impacts a cancer cell’s ability to proliferate in diverse metastatic tissue environments. He will describe two independent studies that (i) connect a form of genetic instability with its causal role in inflammation-driven metastasis, and (ii) uncover a novel therapeutic paradigm that exploits the link between extracellular nutrient availability and cell-intrinsic serine synthesis in brain metastases. Dr. Ngo’s work provides new insight into the mechanisms driving metastasis and how this could lead to innovative therapies.

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Discovery of Novel Antiviral Agents Against Human Pathogenic Viruses: A Tale of Two Emerging Viruses – SARS-CoV-2 and Zika Virus

Discovery of Novel Antiviral Agents Against Human Pathogenic Viruses: A Tale of Two Emerging Viruses – SARS-CoV-2 and Zika Virus

Dr. Jean will discuss his work with novel small-molecule inhibitors and protein-based therapeutics that function against human pathogenic viruses of global public health concern, including SARS-CoV-2 and Zika virus. He will further explain the importance of his research findings for (i) generating effective tools for dissecting pathways in vivo, (ii) defining the biological impact of new therapeutics, and (iii) generating insights into clinical approaches for treating viral diseases caused by emerging human coronaviruses and flaviviruses.

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Inflammation, Infection, and Brain: Neuro-immune communication

Inflammation, Infection, and Brain: Neuro-immune communication

Dr. Lin will present an overview of neuro-immune communication and an introduction to the impacts of COVID-19 on neurological complications. The webinar objectives include Neuro-immune communication, Neurodegenerative disorders and the impacts of SARS-CoV-2 infection on neurological complications.

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The ALS-Reproducible Antibody Platform (ALS-RAP): Identification of high-quality antibodies for ALS research

The ALS-Reproducible Antibody Platform (ALS-RAP): Identification of high-quality antibodies for ALS research

Dr. Laflamme will discuss his published work describing the systematic assessment of antibodies against the C9ORF72 protein as part of ALS-RAP. He will then present intriguing data regarding C9ORF72 biology in macrophages, and will introduce his very exciting and potentially revolutionary efforts to expand the ALS-RAP methodology for antibodies against additional ALS disease proteins as well as those of other neurodegenerative disorders.

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COVID-19 and the Brain

COVID-19 and the Brain

Dr. Eric Song of Yale University will discuss his work that revealed the ability of SARS-CoV-2 to directly infect the mammalian brain (Song et al., J. Exp. Med. 2021). This important study entailed the use of several elegant approaches to demonstrate SARS-CoV-2 infection of both mouse and human brains, with clear implications for the subset of COVID-19 patients experiencing persistent neurological and neuropsychiatric symptoms after resolution of the acute disease. Dr. Song will also provide updates on his current efforts and offer perspectives on future directions of SARS-CoV-2/COVID-19 research.

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