Inflammatory training is the generation of an epigenetic memory that leads to an augmented state of responsiveness to a broad range of secondary stimuli. Though previously thought to be exclusive to the innate immune system, Dr. Samantha Larsen discovered that epithelial stem cells can undergo inflammatory training that accelerates tissue repair. She revealed this phenomenon hinges on the coordinated efforts of stimulus-specific, stress-responsive, and homeostatic transcription factors that extend to diverse stimuli, cell types, and species. She has now extended her interests in the long-term consequences of inflammation to the brain, where she has identified that neurons, much like other long-lived cell types, undergo inflammatory training that may predispose them to subsequent neurodegeneration. Moving forward, she is addressing the persistent transcriptional and electrophysiological changes that follow concussive brain injury with the ultimate goal of treating and preventing injury-induced neuropathogenesis.
When: Tuesday, November 9, 2021 at 9:00 a.m. (EST)
When: 2021年11月5日(金), 11:00 a.m.
Dr. Ngo’s research examines the complex interplay between genomic instability, nutrient constraints, and metabolic synthetic processes that impacts a cancer cell’s ability to proliferate in diverse metastatic tissue environments. He will describe two independent studies that (i) connect a form of genetic instability with its causal role in inflammation-driven metastasis, and (ii) uncover a novel therapeutic paradigm that exploits the link between extracellular nutrient availability and cell-intrinsic serine synthesis in brain metastases. Dr. Ngo’s work provides new insight into the mechanisms driving metastasis and how this could lead to innovative therapies.
Dr. Jean will discuss his work with novel small-molecule inhibitors and protein-based therapeutics that function against human pathogenic viruses of global public health concern, including SARS-CoV-2 and Zika virus. He will further explain the importance of his research findings for (i) generating effective tools for dissecting pathways in vivo, (ii) defining the biological impact of new therapeutics, and (iii) generating insights into clinical approaches for treating viral diseases caused by emerging human coronaviruses and flaviviruses.
Dr. Lin will present an overview of neuro-immune communication and an introduction to the impacts of COVID-19 on neurological complications. The webinar objectives include Neuro-immune communication, Neurodegenerative disorders and the impacts of SARS-CoV-2 infection on neurological complications.
Dr. Laflamme will discuss his published work describing the systematic assessment of antibodies against the C9ORF72 protein as part of ALS-RAP. He will then present intriguing data regarding C9ORF72 biology in macrophages, and will introduce his very exciting and potentially revolutionary efforts to expand the ALS-RAP methodology for antibodies against additional ALS disease proteins as well as those of other neurodegenerative disorders.
Dr. Eric Song of Yale University will discuss his work that revealed the ability of SARS-CoV-2 to directly infect the mammalian brain (Song et al., J. Exp. Med. 2021). This important study entailed the use of several elegant approaches to demonstrate SARS-CoV-2 infection of both mouse and human brains, with clear implications for the subset of COVID-19 patients experiencing persistent neurological and neuropsychiatric symptoms after resolution of the acute disease. Dr. Song will also provide updates on his current efforts and offer perspectives on future directions of SARS-CoV-2/COVID-19 research.