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15 deoxy Delta 12,14 Prostaglandin J2 antibody

Cat. No. GTX22313

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ELISA, RIA

Reactivity

 Species independent
Package
50 μl ($399)
See all Prostaglandin products

APPLICATION

Application Note

Working dilutions are best determined by the end user.

Product Note

This antibody detects Prostaglandin J2 (25.3 %), Prostaglandin D2 (13.13 %), D12-Prostaglandin J2 (8.89 %) and 9a,11b-Prostaglandin F2 alpha (6.93 %).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

15-deoxy-D12,14-Prostaglandin J2 conjugated to a protein carrier molecule

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Prostaglandin J2

Background

15-deoxy-Delta12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Delta12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the gamma isoform of the peroxisome proliferators-activated receptor (PPAR-gamma). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-gamma-independent mechanism mediated by the generation of reactive oxygen species (ROS).

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399