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4-amino Biphenyl DNA antibody [4C11]

Cat. No. GTX30644

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4C11

Isotype

 IgG

Application

 ICC/IF, IHC-Fr, ELISA

Reactivity

 Mouse
Package
100 μl ($419)
See all 4-amino Biphenyl DNA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1:50 - 1:100
IHC-Fr Assay dependent
ELISA 1:100 - 1:2000
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Immunogen

4-amino Biphenyl DNA

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation. 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts.

Research Area

REFERENCE

Clone Reference

McQueen CA et al. Toxicol Sci 2003; 73 (2):279-86 Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity
Application : IHC-Fr
Reactivity : Mouse
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 419