APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 2 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rat, Pig, Elephant, Gibbon, Marmoset, Opossum, Orangutan, Panda(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 15 amino acid peptide from Disintegrin-like domain of human ADAMTS4.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_425091
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ADAM metallopeptidase with thrombospondin type 1 motif 4 , ADAMTS2 , ADAMTS4 , ADMP1 , ADAMTS-4
Cellular Localization
Secreted,Extracellular space,Extracellular matrix
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Database
Research Area
DATA IMAGES
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GTX78143 IHC-P Image
IHC-P analysis of human skin, melanoma tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX78143 IHC-P Image
IHC-P analysis of human kidney tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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GTX78143 IHC-P Image
IHC-P analysis of human cartilage tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval
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REFERENCE
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REVIEW
There are currently no reviews for ADAMTS4 antibody (GTX78143). Be the first to share your experience with this product.
