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ALK antibody [4A4]

Anti-ALK antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX03298

Cat. No. GTX03298

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4A4

Isotype

 IgG2b

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all ALK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50-1:100

Note :

IHC-P
Pretreatment : Citrate Buffer pH 6.0 for 30 min at RT
Not tested in other applications.

Calculated MW

176 kDa. ( Note )

Positive Control

Anaplastic large cell lymphoma

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human ALK protein fragment

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ALK receptor tyrosine kinase , CD246 , NBLST3

Cellular Localization

Cell membrane

Background

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Database

Research Area

DATA IMAGES

Anti-ALK antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX03298

GTX03298 IHC-P Image

IHC-P analysis of human rhabdomyosarcoma tissue section using GTX03298 ALK antibody [4A4].

REFERENCE

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REVIEW

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Package List Price ($)
$ 399