APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.2-2μg/ml |
Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
The epitope recognized is in the region between aa 350 and 400 of AMPK alpha-2.
Predict Reactivity
Rabbit, Guinea pig, Pig, Monkey, Chimpanzee, Gorilla, Orangutan, Chinese Hamster, Northern white-cheeked gibbon, crab-eating macaque, White-tufted-ear marmoset, African elephant, Naked mole rat(>80% identity)
PROPERTIES
Form
Liquid
Buffer
Tris-Citrate/Phosphate
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide representing a portion of the protein encoded within exon 7.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
AMPK , AMPK2 , AMPKa2 , PRKAA , PRKAA2 , protein kinase AMPactivated catalytic subunit alpha 2 , AMPK alpha 2 , protein kinase AMP-activated catalytic subunit alpha 2
Cellular Localization
Cytoplasm,Nucleus
Background
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
Database
Research Area
REFERENCE
There are currently no references for AMPK alpha 2 antibody (GTX23760). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for AMPK alpha 2 antibody (GTX23760). Be the first to share your experience with this product.