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Activin Receptor Type IIA antibody [6J16]

Anti-Activin Receptor Type IIA antibody [6J16] used in IHC (Paraffin sections) (IHC-P). GTX52509

Cat. No. GTX52509

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 6J16

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all Activin Receptor Type IIA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100 - 1:1000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

Product Note

This antibody was selected for its ability to detect human Activin Receptor type IIA. No cross reactivity was found to Activin RI and RIIB

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Activin RIIA extra cellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ACTRII , ACVR2 , ACVR2A , activin A receptor type 2A , Activin Receptor Type IIA , Activin A Receptor type IIA

Cellular Localization

Membrane

Background

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Database

  • Gene ID: 92 ACVR2A
  • UniProt: P27037 ACVR2A

Research Area

DATA IMAGES

Anti-Activin Receptor Type IIA antibody [6J16] used in IHC (Paraffin sections) (IHC-P). GTX52509

GTX52509 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52509 Activin Receptor Type IIA antibody [6J16].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399