APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.75 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Mouse
Immunogen
Peptide (C)RQLKQMESQPLPGER, corresponding to amino acid residues 201-215 of mouse adenosine A2a receptor (Accession Q60613).
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
A2aR,ADORA2,ADORA2A,RDC8,adenosine A2a receptor,Adenosine A2a Receptor,Adenosine A2A-R
Cellular Localization
Cell membrane
Background
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Database
Research Area
DATA IMAGES
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GTX04602 WB Image
WB analysis of various samples using GTX04602 Adenosine A2a Receptor antibody prior incubated with (Lane 3, 4, 6) or without (Lane 1, 2, 5) blocking peptide.
Lane 1 and 3 : Rat aortic endothelial cells
Lane 2 and 4 : Rat brain tissue lysate
Lane 5 and 6 : Jurkat whole cell lysate
Dilution : 1:200
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GTX04602 IHC-P Image
IHC-P analysis of rat lung tissue using GTX04602 Adenosine A2a Receptor antibody. The target signal is expressed in the respiratory epithelium of the bronchioli (Br). And the smooth muscle and endothelium in blood vessels are negative.
Dilution : 1:50
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GTX04602 IHC (Free Floating) Image
IHC (Free floating) analysis of mouse diagonal band using GTX04602 Adenosine A2a Receptor antibody. The target signal appears in the broca of individual neurons (arrows) and in neuropil (asterisk).
Green : Primary antibody
Blue : DAPI
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REFERENCE
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REVIEW
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